From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an
enzyme that in humans is encoded by the PFKFB2
gene .
[5]
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.
[5]
Interactions
PFKFB2 has been shown to
interact with
YWHAQ .
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000123836 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000026409 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b
"Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2" .
^ Pozuelo Rubio M, Peggie Mark, Wong Barry H C, Morrice Nick, MacKintosh Carol (Jul 2003).
"14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase" . EMBO J . 22 (14). England: 3514–23.
doi :
10.1093/emboj/cdg363 .
ISSN
0261-4189 .
PMC
165633 .
PMID
12853467 .
Further reading
Rider MH, Vandamme J, Lebeau E, et al. (1992).
"The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing" . Biochem. J . 285 (2): 405–11.
doi :
10.1042/bj2850405 .
PMC
1132803 .
PMID
1322130 .
Hilliker CE, Darville MI, Aly MS, et al. (1991). "Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization". Genomics . 10 (4): 867–73.
doi :
10.1016/0888-7543(91)90174-D .
PMID
1655632 .
Goldmuntz EA, Remmers EF, Zha H, et al. (1994).
"Genetic map of seven polymorphic markers comprising a single linkage group on rat chromosome 5" . Mamm. Genome . 4 (11): 670–5.
doi :
10.1007/BF00360905 .
PMID
7904197 .
S2CID
1892799 .
Hirata T, Kato M, Okamura N, et al. (1998). "Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines". Biochem. Biophys. Res. Commun . 242 (3): 680–4.
doi :
10.1006/bbrc.1997.8024 .
PMID
9464277 .
Heine-Suñer D, Díaz-Guillén MA, Lange AJ, Rodríguez de Córdoba S (1998).
"Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2)" . Eur. J. Biochem . 254 (1): 103–10.
doi :
10.1046/j.1432-1327.1998.2540103.x .
PMID
9652401 .
Hirata T, Watanabe M, Miura S, et al. (2001).
"Inhibition of tumor cell growth by a specific 6-phosphofructo-2-kinase inhibitor, N-bromoacetylethanolamine phosphate, and its analogues" . Biosci. Biotechnol. Biochem . 64 (10): 2047–52.
doi :
10.1271/bbb.64.2047 .
PMID
11129574 .
S2CID
38413244 .
Kessler R, Eschrich K (2001). "Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain". Brain Res. Mol. Brain Res . 87 (2): 190–5.
doi :
10.1016/S0169-328X(01)00014-6 .
PMID
11245921 .
Soejima H, Kawamoto S, Akai J, et al. (2001). "Isolation of novel heart-specific genes using the BodyMap database". Genomics . 74 (1): 115–20.
doi :
10.1006/geno.2001.6527 .
PMID
11374908 .
Baltrusch S, Lenzen S, Okar DA, et al. (2001).
"Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner" . J. Biol. Chem . 276 (47): 43915–23.
doi :
10.1074/jbc.M105470200 .
PMID
11522786 .
Marsin AS, Bouzin C, Bertrand L, Hue L (2002).
"The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase" . J. Biol. Chem . 277 (34): 30778–83.
doi :
10.1074/jbc.M205213200 .
PMID
12065600 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Pozuelo Rubio M, Peggie M, Wong BH, et al. (2003).
"14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase" . EMBO J . 22 (14): 3514–23.
doi :
10.1093/emboj/cdg363 .
PMC
165633 .
PMID
12853467 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Jin J, Smith FD, Stark C, et al. (2004).
"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Curr. Biol . 14 (16): 1436–50.
Bibcode :
2004CBio...14.1436J .
doi :
10.1016/j.cub.2004.07.051 .
PMID
15324660 .
S2CID
2371325 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Gregory SG, Barlow KF, McLay KE, et al. (2006).
"The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21.
Bibcode :
2006Natur.441..315G .
doi :
10.1038/nature04727 .
PMID
16710414 .
Glycolysis
Gluconeogenesis only
Regulatory