Estradiol Estradiol Enanthate

Estradiol/estradiol enanthate
	Estradiol (top) and; estradiol enanthate (bottom)
Combination of
Estradiol	Estrogen
Estradiol enanthate	Estrogen
Clinical data
Other names	E2/E2-EN; E2/EEn
Routes of; administration	Intramuscular injection

Estradiol/estradiol enanthate (E2/E2-EN) is an injectable combination formulation of estradiol (E2), a short-acting estrogen, and estradiol enanthate (E2-EN), a long-acting estrogen, which was developed by Boehringer around 1960 for potential medical use but was never marketed.^[1]^[2] It contained 1 mg E2 and 9 mg E2-EN in oil solution and was intended for administration by intramuscular injection.^[1]^[2]

A single intramuscular injection of E2/E2-EN (1 mg/9 mg) has been found to result in a 10-fold increase in estradiol excretion on the 2nd day post-injection (due to the 1 mg short-acting E2 component).^[1]^[2] Following this, estradiol excretion remained above the menstrual-cycle average for 10 days post-injection and did not return to baseline until the 24th day post-injection (due to the 9 mg long-acting E2-EN component).^[1]^[2]

E2/E2-EN is similar to estradiol benzoate/estradiol phenylpropionate (brand name Dimenformon Prolongatum), another injectable combination medication of a shorter-acting estrogen (2.5 mg) and a longer-acting estrogen (10 mg).^[1]^[2] In contrast to E2/E2-EN however, estradiol benzoate/estradiol phenylpropionate was marketed for medical use.^[1]^[2]

References

^ ^a ^b ^c ^d ^e ^f Kaiser R (September 1961). "Die Östrogenausscheidung im Zyklus und nach Injektion von Östradiolestern. Ein Beitrag zur Therapie mit Depotöstrogenen" [Estrogen excretion during the cycle and after injection of estradiol esters. A contribution to therapy with depot estrogens]. Geburtshilfe Frauenheilkd (in German). 21: 868–78. ISSN 0016-5751. PMID 13750804.
^ ^a ^b ^c ^d ^e ^f Kaiser, R (1962). "Über die Oestrogenausscheidung nach Injektion von Oestradiolestern" [Estrogen excretion after injection of estradiol esters]. Gewebs-und Neurohormone: Physiologie des Melanophorenhormons [Tissue and Neurohormones: Physiology of the Melanophore Hormone] (in German). Springer, Berlin, Heidelberg. pp. 227–232. doi: 10.1007/978-3-642-86860-3_24. ISBN 978-3-540-02909-0.

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[pmid13750804-1] ^ ^a ^b ^c ^d ^e ^f Kaiser R (September 1961). "Die Östrogenausscheidung im Zyklus und nach Injektion von Östradiolestern. Ein Beitrag zur Therapie mit Depotöstrogenen" [Estrogen excretion during the cycle and after injection of estradiol esters. A contribution to therapy with depot estrogens]. Geburtshilfe Frauenheilkd (in German). 21: 868–78. ISSN 0016-5751. PMID 13750804.

[Kaiser1962-2] ^ ^a ^b ^c ^d ^e ^f Kaiser, R (1962). "Über die Oestrogenausscheidung nach Injektion von Oestradiolestern" [Estrogen excretion after injection of estradiol esters]. Gewebs-und Neurohormone: Physiologie des Melanophorenhormons [Tissue and Neurohormones: Physiology of the Melanophore Hormone] (in German). Springer, Berlin, Heidelberg. pp. 227–232. doi: 10.1007/978-3-642-86860-3_24. ISBN 978-3-540-02909-0.

[1]

[2]

Combination of

Estradiol (top) and estradiol enanthate (bottom)
Estradiol	Estrogen
Estradiol enanthate	Estrogen
Clinical data
Other names	E2/E2-EN; E2/EEn
Routes of administration	Intramuscular injection

See also

References