From Wikipedia, the free encyclopedia
Enzyme
Adenosylcobinamide-GDP ribazoletransferase (
EC
2.7.8.26 , CobS , cobalamin synthase , cobalamin-5'-phosphate synthase , cobalamin (5'-phosphate) synthase ) is an
enzyme with
systematic name adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase .
[1]
[2]
[3] This enzyme
catalyses the following
chemical reaction
(1) adenosylcobinamide-GDP + alpha-ribazole
⇌
{\displaystyle \rightleftharpoons }
GMP +
adenosylcobalamin
(2) adenosylcobinamide-GDP + alpha-ribazole 5'-phosphate
⇌
{\displaystyle \rightleftharpoons }
GMP + adenosylcobalamin 5'-phosphate
This enzyme is part of the biosynthetic pathway to
cobalamin (vitamin B12 ) in
bacteria .
See also
References
^ Maggio-Hall LA, Escalante-Semerena JC (October 1999).
"In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes" . Proceedings of the National Academy of Sciences of the United States of America . 96 (21): 11798–803.
Bibcode :
1999PNAS...9611798M .
doi :
10.1073/pnas.96.21.11798 .
PMC
18366 .
PMID
10518530 .
^ Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (August 2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Natural Product Reports . 19 (4): 390–412.
doi :
10.1039/b108967f .
PMID
12195810 .
^ Cameron B, Blanche F, Rouyez MC, Bisch D, Famechon A, Couder M, Cauchois L, Thibaut D, Debussche L, Crouzet J (October 1991).
"Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5'-phosphate) synthase" . Journal of Bacteriology . 173 (19): 6066–73.
doi :
10.1128/jb.173.19.6066-6073.1991 .
PMC
208353 .
PMID
1917841 .
External links
Activity Regulation Classification Kinetics Types