From Wikipedia, the free encyclopedia
Medication used to treat high blood pressure
Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin ) is an
alpha agonist that is selective to the
alpha-2 adrenergic receptor . Guanabenz is used as an
antihypertensive drug used in the treatment of high blood pressure (
hypertension ).
[1]
[2]
The most common side effects during guanabenz therapy are
dizziness ,
drowsiness ,
dry mouth ,
headache and
weakness .
[3]
Guanabenz can make one drowsy or less alert, therefore driving or operating dangerous machinery is not recommended.
Research
Guanabenz also has some anti-inflammatory properties in different pathological situations, including multiple sclerosis.
[4]
Guanabenz was found in one study to exert an inhibitory effect by decreasing the abundance of the enzyme CH25H, a cholesterol hydroxylase linked to antiviral immunity. Therefore, it is suggested that the drug and similar compounds could be used to treat type I interferon-dependent pathologies and that the CH25H enzyme could be a therapeutic target to control these diseases,
[5] including amyotrophic lateral sclerosis.
See also
References
^ Walker BR, Hare LE, Deitch MW (1982). "Comparative antihypertensive effects of guanabenz and clonidine". The Journal of International Medical Research . 10 (1): 6–14.
doi :
10.1177/030006058201000102 .
PMID
7037502 .
S2CID
2139809 . [
permanent dead link ]
^ Bonham AC, Trapani AJ, Portis LR, Brody MJ (December 1984).
"Studies on the mechanism of the central antihypertensive effect of guanabenz and clonidine" . Journal of Hypertension Supplement . 2 (3): S543–S546.
PMID
6599714 . [
permanent dead link ]
^
"Guanabenz | The Merck Index Online" . www.rsc.org . Retrieved 2023-04-17 .
^ Way SW, Podojil JR, Clayton BL, Zaremba A, Collins TL, Kunjamma RB, et al. (March 2015).
"Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic" . Nature Communications . 6 : 6532.
Bibcode :
2015NatCo...6.6532W .
doi :
10.1038/ncomms7532 .
PMC
4360920 .
PMID
25766071 .
^ Perego J, Mendes A, Bourbon C, Camosseto V, Combes A, Liu H, et al. (January 2018). "Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex". Science Signaling . 11 (514): eaam8104.
doi :
10.1126/scisignal.aam8104 .
hdl :
10773/27856 .
PMID
29363586 .
S2CID
13680678 .
α1
Agonists Antagonists
Abanoquil
Ajmalicine
Alfuzosin
Anisodamine
Anisodine
Atiprosin
Atypical antipsychotics (e.g.,
brexpiprazole ,
clozapine ,
olanzapine ,
quetiapine ,
risperidone )
Benoxathian
Beta blockers (e.g.,
adimolol ,
amosulalol ,
arotinolol ,
carvedilol ,
eugenodilol ,
labetalol )
Buflomedil
Bunazosin
Corynanthine
Dapiprazole
Domesticine
Doxazosin
Ergolines (e.g.,
acetergamine ,
ergotamine ,
dihydroergotamine ,
lisuride ,
nicergoline ,
terguride )
Etoperidone
Fenspiride
Hydroxyzine
Indoramin
Ketanserin
L-765,314
mCPP
Mepiprazole
Metazosin
Monatepil
Moxisylyte
Naftopidil
Nantenine
Neldazosin
Niaprazine
Niguldipine
Pardoprunox
Pelanserin
Perlapine
Phendioxan
Phenoxybenzamine
Phentolamine
Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone ,
nefazodone ,
trazodone ,
triazoledione )
Piperoxan
Prazosin
Quinazosin
Quinidine
Silodosin
Spegatrine
Spiperone
Talipexole
Tamsulosin
Terazosin
Tiodazosin
Tolazoline
Tetracyclic antidepressants (e.g.,
amoxapine ,
maprotiline ,
mianserin )
Tricyclic antidepressants (e.g.,
amitriptyline ,
clomipramine ,
doxepin ,
imipramine ,
trimipramine )
Trimazosin
Typical antipsychotics (e.g.,
chlorpromazine ,
fluphenazine ,
loxapine ,
thioridazine )
Urapidil
WB-4101
Zolertine
α2
Agonists Antagonists
1-PP
Adimolol
Amesergide
Aptazapine
Atipamezole
Atypical antipsychotics (e.g.,
asenapine ,
brexpiprazole ,
clozapine ,
lurasidone ,
olanzapine ,
paliperidone ,
quetiapine ,
risperidone ,
zotepine )
Azapirones (e.g.,
buspirone ,
gepirone ,
ipsapirone ,
tandospirone )
BRL-44408
Buflomedil
Cirazoline
Efaroxan
Esmirtazapine
Fenmetozole
Fluparoxan
Idazoxan
Ketanserin
Lisuride
mCPP
Mianserin
Mirtazapine
NAN-190
Pardoprunox
Phentolamine
Phenoxybenzamine
Piperoxan
Piribedil
Rauwolscine
Rotigotine
Setiptiline
Spegatrine
Spiroxatrine
Sunepitron
Terguride
Tolazoline
Typical antipsychotics (e.g.,
chlorpromazine ,
fluphenazine ,
loxapine ,
thioridazine )
Yohimbine
β