From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
NECTIN1 Identifiers
Aliases
NECTIN1 , CD111, CLPED1, ED4, HIgR, HV1S, HVEC, OFC7, PRR, PRR1, PVRR, PVRR1, SK-12, nectin-1, PVRL1, nectin cell adhesion molecule 1External IDs
OMIM :
600644 ;
MGI :
1926483 ;
HomoloGene :
2138 ;
GeneCards :
NECTIN1 ;
OMA :
NECTIN1 - orthologs
Wikidata
Poliovirus receptor-related 1 (PVRL1 ), also known as nectin-1 and CD111 (formerly herpesvirus entry mediator C , HVEC ) is a human protein of the
immunoglobulin superfamily (IgSF), also considered a member of the
nectins .
[5] It is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail. The protein can mediate
Ca2+ -independent
cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM).
Function
PVRL1 is an adhesion molecule found in a wide range of tissues where it localizes in various junctions such as the
adherens junction of
epithelial tissue or the
chemical synapse of
neurons . The cytoplasmic tail of PVRL1 can bind the protein
afadin which is a scaffolding protein that binds
actin .
In the chemical synapse PVRL1 interacts with
PVRL3 (nectin-3) and both proteins can be found in neuronal tissue already in early stages of brain development as well as in aging brains. The two proteins have been found to localize asymmetrically along the chemical synapse, with PVRL1 primarily on the
axonal side and PVRL3 on the
dendritic side.
The protein has been revealed as one of the key players in mediating cellular entry of the
Herpes simplex virus by interacting with the viral glycoprotein D (gD).
[6]
See also
Interactions
PVRL1 has been shown to
interact with
MLLT4 .
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000110400 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000032012 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Entrez Gene: PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)" .
^ Cocchi F, Lopez M, Menotti L, Aoubala M, Dubreuil P, Campadelli-Fiume G (1999).
"The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D" . Proc. Natl. Acad. Sci. U.S.A . 95 (26): 15700–5.
doi :
10.1073/pnas.95.26.15700 .
PMC
28107 .
PMID
9861033 .
^ Takahashi K, Nakanishi H, Miyahara M, Mandai K, Satoh K, Satoh A, Nishioka H, Aoki J, Nomoto A, Mizoguchi A, Takai Y (May 1999).
"Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein" . J. Cell Biol . 145 (3): 539–49.
doi :
10.1083/jcb.145.3.539 .
PMC
2185068 .
PMID
10225955 .
Further reading
Bustos T, Simosa V, Pinto-Cisternas J, Abramovits W, Jolay L, Rodriguez L, Fernandez L, Ramela M (1992). "Autosomal recessive ectodermal dysplasia: I. An undescribed dysplasia/malformation syndrome". Am. J. Med. Genet . 41 (4): 398–404.
doi :
10.1002/ajmg.1320410403 .
PMID
1776626 .
Lopez M, Eberlé F, Mattei MG, Gabert J, Birg F, Bardin F, Maroc C, Dubreuil P (1995). "Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene". Gene . 155 (2): 261–5.
doi :
10.1016/0378-1119(94)00842-G .
PMID
7721102 .
Bonaldo MF, Lennon G, Soares MB (1997).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Geraghty RJ, Krummenacher C, Cohen GH, Eisenberg RJ, Spear PG (1998). "Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor". Science . 280 (5369): 1618–20.
Bibcode :
1998Sci...280.1618G .
doi :
10.1126/science.280.5369.1618 .
PMID
9616127 .
Suzuki K, Bustos T, Spritz RA (1998).
"Linkage disequilibrium mapping of the gene for Margarita Island ectodermal dysplasia (ED4) to 11q23" . Am. J. Hum. Genet . 63 (4): 1102–7.
doi :
10.1086/302072 .
PMC
1377504 .
PMID
9758630 .
Cocchi F, Menotti L, Mirandola P, Lopez M, Campadelli-Fiume G (1998).
"The Ectodomain of a Novel Member of the Immunoglobulin Subfamily Related to the Poliovirus Receptor Has the Attributes of a Bona Fide Receptor for Herpes Simplex Virus Types 1 and 2 in Human Cells" . J. Virol . 72 (12): 9992–10002.
doi :
10.1128/JVI.72.12.9992-10002.1998 .
PMC
110516 .
PMID
9811737 .
Cocchi F, Lopez M, Menotti L, Aoubala M, Dubreuil P, Campadelli-Fiume G (1999).
"The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D" . Proc. Natl. Acad. Sci. U.S.A . 95 (26): 15700–5.
doi :
10.1073/pnas.95.26.15700 .
PMC
28107 .
PMID
9861033 .
Takahashi K, Nakanishi H, Miyahara M, Mandai K, Satoh K, Satoh A, Nishioka H, Aoki J, Nomoto A, Mizoguchi A, Takai Y (1999).
"Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein" . J. Cell Biol . 145 (3): 539–49.
doi :
10.1083/jcb.145.3.539 .
PMC
2185068 .
PMID
10225955 .
Miyahara M, Nakanishi H, Takahashi K, Satoh-Horikawa K, Tachibana K, Takai Y (2000).
"Interaction of nectin with afadin is necessary for its clustering at cell–cell contact sites but not for its cis dimerization or trans interaction" . J. Biol. Chem . 275 (1): 613–8.
doi :
10.1074/jbc.275.1.613 .
PMID
10617658 .
Suzuki K, Hu D, Bustos T, Zlotogora J, Richieri-Costa A, Helms JA, Spritz RA (2000). "Mutations of PVRL1, encoding a cell–cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia". Nat. Genet . 25 (4): 427–30.
doi :
10.1038/78119 .
PMID
10932188 .
S2CID
6169893 .
Lopez M, Cocchi F, Avitabile E, Leclerc A, Adelaide J, Campadelli-Fiume G, Dubreuil P (2001).
"Novel, Soluble Isoform of the Herpes Simplex Virus (HSV) Receptor Nectin1 (or PRR1-HIgR-HveC) Modulates Positively and Negatively Susceptibility to HSV Infection" . J. Virol . 75 (12): 5684–91.
doi :
10.1128/JVI.75.12.5684-5691.2001 .
PMC
114282 .
PMID
11356977 .
Sözen MA, Suzuki K, Tolarova MM, Bustos T, Fernández Iglesias JE, Spritz RA (2001). "Mutation of PVRL1 is associated with sporadic, non-syndromic cleft lip/palate in northern Venezuela". Nat. Genet . 29 (2): 141–2.
doi :
10.1038/ng740 .
PMID
11559849 .
S2CID
8641206 .
Struyf F, Posavad CM, Keyaerts E, Van Ranst M, Corey L, Spear PG (2002).
"Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals" . J. Infect. Dis . 185 (1): 36–44.
doi :
10.1086/338116 .
PMID
11756979 .
Fabre S, Reymond N, Cocchi F, Menotti L, Dubreuil P, Campadelli-Fiume G, Lopez M (2002).
"Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain" . J. Biol. Chem . 277 (30): 27006–13.
doi :
10.1074/jbc.M203228200 .
PMID
12011057 .
Yoon M, Spear PG (2002).
"Disruption of Adherens Junctions Liberates Nectin-1 To Serve as Receptor for Herpes Simplex Virus and Pseudorabies Virus Entry" . J. Virol . 76 (14): 7203–8.
doi :
10.1128/JVI.76.14.7203-7208.2002 .
PMC
136315 .
PMID
12072519 .
Struyf F, Martinez WM, Spear PG (2002).
"Mutations in the N-Terminal Domains of Nectin-1 and Nectin-2 Reveal Differences in Requirements for Entry of Various Alphaherpesviruses and for Nectin-Nectin Interactions" . J. Virol . 76 (24): 12940–50.
doi :
10.1128/JVI.76.24.12940-12950.2002 .
PMC
136698 .
PMID
12438620 .
Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (2003).
"Direct binding of cell polarity protein PAR-3 to cell–cell adhesion molecule nectin at neuroepithelial cells of developing mouse" . J. Biol. Chem . 278 (8): 5497–500.
doi :
10.1074/jbc.C200707200 .
PMID
12515806 .
Krummenacher C, Baribaud I, Eisenberg RJ, Cohen GH (2003).
"Cellular Localization of Nectin-1 and Glycoprotein D during Herpes Simplex Virus Infection" . J. Virol . 77 (16): 8985–99.
doi :
10.1128/JVI.77.16.8985-8999.2003 .
PMC
167240 .
PMID
12885915 .
Bender FC, Whitbeck JC, Ponce de Leon M, Lou H, Eisenberg RJ, Cohen GH (2003).
"Specific Association of Glycoprotein B with Lipid Rafts during Herpes Simplex Virus Entry" . J. Virol . 77 (17): 9542–52.
doi :
10.1128/JVI.77.17.9542-9552.2003 .
PMC
187402 .
PMID
12915568 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
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