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Chemical compound
3,4-Dichloro-alpha-PVP
1-(3,4-dichlorophenyl)-2-(pyrrolidin-1-yl)pentan-1-one
CAS Number
PubChem
CID
ChemSpider
Formula C 15 H 19 Cl 2 N O
Molar mass 300.22 g·mol−1 3D model (
JSmol )
CCCC(C(=O)C1=CC(=C(C=C1)Cl)Cl)N2CCCC2
InChI=1S/C15H19Cl2NO/c1-2-5-14(18-8-3-4-9-18)15(19)11-6-7-12(16)13(17)10-11/h6-7,10,14H,2-5,8-9H2,1H3
Key:OYYFMZJTKZIRQM-UHFFFAOYSA-N
O-2390 (3,4-Dichloro-alpha-PVP , DCPVP ) is a recreational
designer drug from the
substituted cathinone family, which acts as a potent inhibitor of
dopamine and
noradrenaline
reuptake in vitro , with weaker but still significant inhibition of
serotonin reuptake.
[1]
[2]
[3]
[4]
See also
References
^ Meltzer PC, Butler D, Deschamps JR, Madras BK (February 2006).
"1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors" . Journal of Medicinal Chemistry . 49 (4): 1420–1432.
doi :
10.1021/jm050797a .
PMC
2602954 .
PMID
16480278 .
^ Kolanos R, Sakloth F, Jain AD, Partilla JS, Baumann MH, Glennon RA (October 2015).
"Structural Modification of the Designer Stimulant α-Pyrrolidinovalerophenone (α-PVP) Influences Potency at Dopamine Transporters" . ACS Chemical Neuroscience . 6 (10): 1726–1731.
doi :
10.1021/acschemneuro.5b00160 .
PMC
5349767 .
PMID
26217965 .
^ Glennon RA, Young R (September 2016).
"Neurobiology of 3,4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinovalerophenone (α-PVP)" . Brain Research Bulletin . 126 (Pt 1): 111–126.
doi :
10.1016/j.brainresbull.2016.04.011 .
PMC
5817884 .
PMID
27142261 .
^ Yadav-Samudrala BJ, Eltit JM, Glennon RA (September 2019). "Synthetic Cathinone Analogues Structurally Related to the Central Stimulant Methylphenidate as Dopamine Reuptake Inhibitors". ACS Chemical Neuroscience . 10 (9): 4043–4050.
doi :
10.1021/acschemneuro.9b00284 .
PMID
31369229 .
S2CID
199380459 .