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Chemical compound
Gliquidone
Trade names Glurenorm
AHFS /
Drugs.com
International Drug Names
Pregnancy category
Routes of administration Oral (
tablets )
ATC code
Legal status
UK :
POM (Prescription only)
In general: ℞ (Prescription only)
Bioavailability High (
Tmax = 2–3 hours)
Metabolism Extensive
hepatic
Onset of action 1–1.5 hours
Excretion
Biliary (95%),
renal (5%)
1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea
CAS Number
PubChem
CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (
EPA )
ECHA InfoCard
100.046.770
Formula C 27 H 33 N 3 O 6 S
Molar mass 527.64 g·mol−1 3D model (
JSmol )
O=C(NC1CCCCC1)NS(=O)(=O)c2ccc(cc2)CCN4C(=O)c3c(ccc(OC)c3)C(C4=O)(C)C
InChI=1S/C27H33N3O6S/c1-27(2)23-14-11-20(36-3)17-22(23)24(31)30(25(27)32)16-15-18-9-12-21(13-10-18)37(34,35)29-26(33)28-19-7-5-4-6-8-19/h9-14,17,19H,4-8,15-16H2,1-3H3,(H2,28,29,33)
Y Key:LLJFMFZYVVLQKT-UHFFFAOYSA-N
Y
(verify)
Gliquidone (
INN , sold under the trade name Glurenorm ) is an
anti-diabetic medication in the
sulfonylurea class.
[1] It is classified as a second-generation sulfonylurea. It is used in the treatment of
diabetes mellitus type 2 . It is marketed by the pharmaceutical company
Boehringer Ingelheim (Germany).
Contraindications
Pharmacokinetics
Gliquidone is fully metabolized by the liver. Its metabolites are excreted virtually completely with bile (even with long-term administration), thus allowing the use of medication in diabetic patients with kidney disease and
diabetic nephropathy .
[2]
References
fast-acting short-acting long-acting ultra-long-acting
inhalable
Calcium
VDCCs Tooltip Voltage-dependent calcium channels
Potassium
VGKCs Tooltip Voltage-gated potassium channels
IRKs Tooltip Inwardly rectifying potassium channel
KCa Tooltip Calcium-activated potassium channel
K2Ps Tooltip Tandem pore domain potassium channel
Sodium
VGSCs Tooltip Voltage-gated sodium channels
ENaC Tooltip Epithelial sodium channel
ASICs Tooltip Acid-sensing ion channel
Chloride
CaCCs Tooltip Calcium-activated chloride channel
CFTR Tooltip Cystic fibrosis transmembrane conductance regulator
Unsorted
Others
TRPs Tooltip Transient receptor potential channels
LGICs Tooltip Ligand gated ion channels