From Wikipedia, the free encyclopedia
Aleglitazar
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Names
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Preferred IUPAC name
(2S)-2-Methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid
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Other names
Ro-0728804, R-1439
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Identifiers
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ChEMBL
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ChemSpider
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DrugBank
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ECHA InfoCard
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100.220.523
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KEGG
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UNII
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InChI=1S/C24H23NO5S/c1-15-19(25-23(30-15)16-6-4-3-5-7-16)10-12-29-20-9-8-17(14-21(28-2)24(26)27)22-18(20)11-13-31-22/h3-9,11,13,21H,10,12,14H2,1-2H3,(H,26,27)/t21-/m0/s1 YKey: DAYKLWSKQJBGCS-NRFANRHFSA-N YInChI=1/C24H23NO5S/c1-15-19(25-23(30-15)16-6-4-3-5-7-16)10-12-29-20-9-8-17(14-21(28-2)24(26)27)22-18(20)11-13-31-22/h3-9,11,13,21H,10,12,14H2,1-2H3,(H,26,27)/t21-/m0/s1 Key: DAYKLWSKQJBGCS-NRFANRHFBF
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CC1=C(CCOc2ccc(C[C@H](OC)C(O[H])=O)c3c2C=CS3)N=C(c4ccccc4)O1 O=C(O)[C@@H](OC)Cc4ccc(OCCc1nc(oc1C)c2ccccc2)c3c4scc3
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Properties
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C24H23NO5S
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Molar mass
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437.51 g·mol−1
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Aleglitazar is a
peroxisome proliferator-activated receptor
agonist (hence a
PPAR modulator ) with affinity to PPARα and PPARγ, which was under development by
Hoffmann–La Roche for the treatment of
type II diabetes.
[1] It is no longer in
phase III clinical trials.
[2]
References
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fast-acting | |
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short-acting | |
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long-acting | |
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ultra-long-acting | |
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inhalable | |
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PPARαTooltip Peroxisome proliferator-activated receptor alpha | |
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PPARδTooltip Peroxisome proliferator-activated receptor delta | |
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PPARγTooltip Peroxisome proliferator-activated receptor gamma | |
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Non-selective | |
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