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Antihypertensive drug of the calcium channel blocker class
Benidipine
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International Drug Names |
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Routes of administration | By mouth |
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ATC code | |
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O5-methyl O3-[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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PubChem
CID | |
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ChemSpider | |
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UNII | |
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ChEMBL | |
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Formula | C28H31N3O6 |
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Molar mass | 505.571 g·mol−1 |
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3D model (
JSmol) | |
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[O-][N+](=O)c1cccc(c1)[C@@H]4C(/C(=O)OC)=C(\N\C(=C4\C(=O)O[C@@H]3CCCN(Cc2ccccc2)C3)C)C
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InChI=1S/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1 NKey:QZVNQOLPLYWLHQ-ZEQKJWHPSA-N N
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Benidipine is a dihydropyridine calcium channel blocker for the treatment of
high blood pressure (hypertension). It is a triple L-, T-, and N-type
calcium channel blocker. It is reno- and cardioprotective.
It was patented in 1981 and approved for medical use in 1991.
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Dosing
Benidipine is dosed as 2–8 mg once daily.
[2]
Mechanism
Benidipine is a
calcium channel blocker.
Benidipine has additionally been found to act as an
antagonist of the
mineralocorticoid receptor, or as an
antimineralocorticoid.
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Names
Other names include Benidipinum or benidipine hydrochloride.
Benidipine is sold as Coniel by Kyowa Hakko Kogyo.
Benidipine is initially licensed for use in Japan and selected
Southeast Asian countries and later in Turkey, where it is sold as 4 mg tablets.
References
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Calcium |
VDCCsTooltip Voltage-dependent calcium channels | |
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Potassium |
VGKCsTooltip Voltage-gated potassium channels | |
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IRKsTooltip Inwardly rectifying potassium channel | |
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KCaTooltip Calcium-activated potassium channel | |
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K2PsTooltip Tandem pore domain potassium channel | |
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Sodium |
VGSCsTooltip Voltage-gated sodium channels | |
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ENaCTooltip Epithelial sodium channel | |
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ASICsTooltip Acid-sensing ion channel | |
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Chloride |
CaCCsTooltip Calcium-activated chloride channel | |
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CFTRTooltip Cystic fibrosis transmembrane conductance regulator | |
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Unsorted | |
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Others |
TRPsTooltip Transient receptor potential channels | |
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LGICsTooltip Ligand gated ion channels | |
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MRTooltip Mineralocorticoid receptor | |
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