ADGRV1, also known as G protein-coupled receptor 98 (GPR98) or Very Large G-protein coupled receptor 1 (VLGR1), is a
protein that in humans is encoded by the GPR98gene.[5] Several alternatively spliced transcripts have been described.[5]
The adhesion GPCR VLGR1 is the largest GPCR known, with a size of 6300 amino acids and consisting of 90 exons.[6] There are 8 splice variants of VlgR1, named VlgR1a-1e and Mass1.1-1.3. The
N-terminus consists of 5800 amino acids containing 35 Calx-beta domains, one pentraxin domain, and one epilepsy associated repeat. Mutations of VlgR1 have been shown to result in Usher's syndrome. Knockouts of Vlgr1 in mice have been shown to phenocopy Usher's syndrome and lead to audiogenic seizures.
Function
This gene encodes a member of the
adhesion-GPCR family of receptors.[7] The protein binds calcium and is expressed in the central nervous system. It is also known as very large G-protein coupled receptor 1 because it is 6300 residues long. It contains a C-terminal 7-transmembrane receptor domain, whereas the large N-terminal segment (5900 residues) includes 35 calcium binding
Calx-beta domains, and 6
EAR domains.
Evolution
The
sea urchin genome has a homolog of VLGR1 in it.[8]
Clinical significance
Mutations in this gene are associated with
Usher syndrome 2 and familial febrile seizures.[5]
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Schwartz SB, Aleman TS, Cideciyan AV, et al. (2005). "Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype". Invest. Ophthalmol. Vis. Sci. 46 (2): 734–43.
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