From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Taste receptor type 2 member 7 is a
protein that in humans is encoded by the TAS2R7
gene .
[5]
[6]
[7]
Function
This gene product belongs to the family of candidate
taste receptors that are members of the
G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the
genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on
chromosome 12p 13.
[7]
See also
References
^
a
b
c
ENSG00000273326, ENSG00000274327 GRCh38: Ensembl release 89: ENSG00000121377, ENSG00000273326, ENSG00000274327 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000054497 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000).
"A novel family of mammalian taste receptors" . Cell . 100 (6): 693–702.
doi :
10.1016/S0092-8674(00)80705-9 .
PMID
10761934 .
S2CID
14604586 .
^ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature . 404 (6778): 601–4.
Bibcode :
2000Natur.404..601M .
doi :
10.1038/35007072 .
PMID
10766242 .
S2CID
4336913 .
^
a
b
"Entrez Gene: TAS2R7 taste receptor, type 2, member 7" .
Further reading
Kinnamon SC (2000).
"A plethora of taste receptors" . Neuron . 25 (3): 507–10.
doi :
10.1016/S0896-6273(00)81054-5 .
PMID
10774719 .
Margolskee RF (2002).
"Molecular mechanisms of bitter and sweet taste transduction" . J. Biol. Chem . 277 (1): 1–4.
doi :
10.1074/jbc.R100054200 .
PMID
11696554 .
Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol . 12 (4): 366–71.
doi :
10.1016/S0959-4388(02)00345-8 .
PMID
12139982 .
S2CID
37807140 .
Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000).
"T2Rs function as bitter taste receptors" . Cell . 100 (6): 703–11.
doi :
10.1016/S0092-8674(00)80706-0 .
PMID
10761935 .
S2CID
7293493 .
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003).
"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways" . Cell . 112 (3): 293–301.
doi :
10.1016/S0092-8674(03)00071-0 .
PMID
12581520 .
S2CID
718601 .
Fischer A, Gilad Y, Man O, Pääbo S (2005).
"Evolution of bitter taste receptors in humans and apes" . Mol. Biol. Evol . 22 (3): 432–6.
doi :
10.1093/molbev/msi027 .
PMID
15496549 .
Go Y, Satta Y, Takenaka O, Takahata N (2006).
"Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates" . Genetics . 170 (1): 313–26.
doi :
10.1534/genetics.104.037523 .
PMC
1449719 .
PMID
15744053 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .