From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Taste receptor type 2 member 3 is a
protein that in humans is encoded by the TAS2R3
gene .
[5]
Function
This gene encodes a member of a family of candidate
taste receptors that are members of the
G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.
[5]
Ligands
The only known ligand for TAS2R3 in
BitterDB is
chloroquine .
[6]
See also
References
Further reading
Kinnamon SC (2000).
"A plethora of taste receptors" . Neuron . 25 (3): 507–10.
doi :
10.1016/S0896-6273(00)81054-5 .
PMID
10774719 .
Margolskee RF (2002).
"Molecular mechanisms of bitter and sweet taste transduction" . J. Biol. Chem . 277 (1): 1–4.
doi :
10.1074/jbc.R100054200 .
PMID
11696554 .
Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol . 12 (4): 366–71.
doi :
10.1016/S0959-4388(02)00345-8 .
PMID
12139982 .
S2CID
37807140 .
Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000).
"A novel family of mammalian taste receptors" . Cell . 100 (6): 693–702.
doi :
10.1016/S0092-8674(00)80705-9 .
PMID
10761934 .
S2CID
14604586 .
Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000).
"T2Rs function as bitter taste receptors" . Cell . 100 (6): 703–11.
doi :
10.1016/S0092-8674(00)80706-0 .
PMID
10761935 .
S2CID
7293493 .
Firestein S (2000).
"The good taste of genomics" . Nature . 404 (6778): 552–3.
doi :
10.1038/35007167 .
PMID
10766221 .
S2CID
35741332 .
Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse". Nature . 404 (6778): 601–4.
Bibcode :
2000Natur.404..601M .
doi :
10.1038/35007072 .
PMID
10766242 .
S2CID
4336913 .
Ueda T, Ugawa S, Ishida Y, Shibata Y, Murakami S, Shimada S (2001). "Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting". Biochem. Biophys. Res. Commun . 285 (1): 147–51.
doi :
10.1006/bbrc.2001.5136 .
PMID
11437385 .
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003).
"Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways" . Cell . 112 (3): 293–301.
doi :
10.1016/S0092-8674(03)00071-0 .
PMID
12581520 .
S2CID
718601 .
Fischer A, Gilad Y, Man O, Pääbo S (2005).
"Evolution of bitter taste receptors in humans and apes" . Mol. Biol. Evol . 22 (3): 432–6.
doi :
10.1093/molbev/msi027 .
PMID
15496549 .
Go Y, Satta Y, Takenaka O, Takahata N (2006).
"Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates" . Genetics . 170 (1): 313–26.
doi :
10.1534/genetics.104.037523 .
PMC
1449719 .
PMID
15744053 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .