From Wikipedia, the free encyclopedia
Chemical compound
Trapidil is a
vasodilator and an
antiplatelet drug .
[1]
[2] It also acts as an antagonist of
platelet-derived growth factor .
[3]
An
analog was assigned the codename AR 12-456.
[4]
References
^ Büyükafşar K, Yazar A, Düşmez D, Oztürk H, Polat G, Levent A (October 2001). "Effect of trapidil, an antiplatelet and vasodilator agent on gentamicin-induced nephrotoxicity in rats". Pharmacological Research . 44 (4): 321–328.
doi :
10.1006/phrs.2001.0864 .
PMID
11592868 .
^ Liu M, Sun Q, Wang Q, Wang X, Lin P, Yang M, Yan Y (March–April 2014).
"Effect of trapidil in myocardial ischemia-reperfusion injury in rabbit" . Indian Journal of Pharmacology . 46 (2): 207–210.
doi :
10.4103/0253-7613.129320 .
PMC
3987192 .
PMID
24741195 .
^ Maresta A, Balducelli M, Cantini L, Casari A, Chioin R, Fabbri M, et al. (December 1994).
"Trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, reduces restenosis after percutaneous transluminal coronary angioplasty. Results of the randomized, double-blind STARC study. Studio Trapidil versus Aspirin nella Restenosi Coronarica" . Circulation . 90 (6): 2710–2715.
doi :
10.1161/01.cir.90.6.2710 .
PMID
7994812 .
^ Hering S, Bodewei R, Schubert B, Krause EG, Wollenberger A (1985). "Trapidil and other 5-triazolo-(1, 5-alpha)-pyrimidine derivatives as calcium channel blockers in 108CC5 cells". Biomedica Biochimica Acta . 44 (5): K37–K41.
PMID
2415119 .