Enoximone

Enoximone
Clinical data
Trade names	Perfan
AHFS/ Drugs.com	International Drug Names
Routes of; administration	Intravenous
ATC code	C01CE03 ( WHO) ;
Legal status
Legal status	UK: POM (Prescription only);
Pharmacokinetic data
Bioavailability	50% (oral)
Protein binding	85%
Metabolism	Liver ( oxidation)
Elimination half-life	4 to 10 hours
Excretion	Renal (60 to 70%)
Identifiers
	IUPAC name 4-Methyl-5-{[4-(methylsulfanyl)phenyl]carbonyl}-2,3-dihydro-1H-imidazol-2-one;
CAS Number	77671-31-9 ;
PubChem CID	53708;
DrugBank	DB04880 ;
ChemSpider	48492 ;
UNII	C7Z4ITI7L7;
KEGG	D04004 ;
ChEMBL	ChEMBL249856 ;
CompTox Dashboard ( EPA)	DTXSID8045147 ;
Chemical and physical data
Formula	C12H12N2O2S
Molar mass	248.30 g·mol−1
3D model ( JSmol)	Interactive image;
Melting point	255 to 258 °C (491 to 496 °F) (decomposes)
	SMILES O=C(/C1=C(/NC(=O)N1)C)c2ccc(SC)cc2;
	InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) ; Key:ZJKNESGOIKRXQY-UHFFFAOYSA-N ;
	(verify)

Enoximone ( INN, trade name Perfan) is an imidazole phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure and is selective for phosphodiesterase 3.^[1]

References

^ Boldt J, Suttner S (September 2007). "Combined use of ultra-short acting beta-blocker esmolol and intravenous phosphodiesterase 3 inhibitor enoximone". Expert Opin Pharmacother. 8 (13): 2135–47. doi: 10.1517/14656566.8.13.2135. PMID 17714066. S2CID 46021219.

External links

Media related to Enoximone at Wikimedia Commons

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[pmid17714066-1] Boldt J, Suttner S (September 2007). "Combined use of ultra-short acting beta-blocker esmolol and intravenous phosphodiesterase 3 inhibitor enoximone". Expert Opin Pharmacother. 8 (13): 2135–47. doi: 10.1517/14656566.8.13.2135. PMID 17714066. S2CID 46021219.

[1]

v t e Phosphodiesterase inhibitors
PDE1	MMPX SCH-51866 Vinpocetine
PDE2	BAY 60-7550 Carbazeran EHNA Oxindole PDP
PDE3	Adibendan Amrinone (inamrinone) Anagrelide Benafentrine Bucladesine Carbazeran Cilostamide Cilostazol Enoximone Imazodan KMUP-1 Meribendan Milrinone Olprinone Parogrelil Pimobendan Pumafentrine Quazinone RPL-554 Siguazodan Trequinsin Vesnarinone Zardaverine
PDE4	Apremilast Arofylline Atizoram Benafentrine Catramilast CC-1088 CDP-840 CGH-2466 Cilomilast Cipamfylline Crisaborole Denbutylline Difamilast Drotaverine Etazolate Filaminast Glaucine HT-0712 ICI-63197 Indimilast Irsogladine Lavamilast Lirimilast Lotamilast Luteolin Mesembrenone Mesembrine Mesopram Oglemilast Piclamilast Pumafentrine Revamilast Ro 20-1724 Roflumilast Rolipram Ronomilast RPL-554 RS-25344 Tetomilast Tofimilast YM-976 Zardaverine
PDE5	Acetildenafil Aildenafil Avanafil Beminafil Benzamidenafil Dasantafil Icariin Gisadenafil Homosildenafil Lodenafil Mirodenafil MY-5445 Nitrosoprodenafil Norcarbodenafil SCH-51866 Sildenafil Sulfoaildenafil T-0156 Tadalafil Udenafil Vardenafil
PDE7	BRL-50481
PDE9	BAY 73-6691 PF-04447943 Paraxanthine
PDE10	Balipodect Mardepodect Papaverine TC-E 5005 Tofisopam
PDE11	BC11-38
Non-selective	Aminophylline Caffeine Choline theophyllinate CPX Dipyridamole Doxofylline Enprofylline Ibudilast IBMX Luteolin Pentoxifylline Propentofylline Theobromine Theophylline Zaprinast
Unsorted	Diazepam Diprophylline DPCPX Furafylline Lisofylline MDL-12330A Moxaverine Oxagrelate Pentifylline Proxyphylline Quercetin Satigrel Tolafentrine Trapidil
See also: Receptor/signaling modulators

Clinical data

Trade names	Perfan
AHFS/ Drugs.com	International Drug Names
Routes of administration	Intravenous
ATC code	C01CE03 ( WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability	50% (oral)
Protein binding	85%
Metabolism	Liver ( oxidation)
Elimination half-life	4 to 10 hours
Excretion	Renal (60 to 70%)
Identifiers
IUPAC name 4-Methyl-5-{[4-(methylsulfanyl)phenyl]carbonyl}-2,3-dihydro-1H-imidazol-2-one
CAS Number	77671-31-9^Y
PubChem CID	53708
DrugBank	DB04880^Y
ChemSpider	48492^Y
UNII	C7Z4ITI7L7
KEGG	D04004^Y
ChEMBL	ChEMBL249856^Y
CompTox Dashboard ( EPA)	DTXSID8045147
Chemical and physical data
Formula	C₁₂H₁₂N₂O₂S
Molar mass	248.30 g·mol⁻¹
3D model ( JSmol)	Interactive image
Melting point	255 to 258 °C (491 to 496 °F) (decomposes)
SMILES O=C(/C1=C(/NC(=O)N1)C)c2ccc(SC)cc2
InChI InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)^Y Key:ZJKNESGOIKRXQY-UHFFFAOYSA-N^Y
(verify)