From Wikipedia, the free encyclopedia
MRS-1706
Names
IUPAC name
N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide
Other names
MRS 1706
Identifiers
ChemSpider
MeSH
C496145
UNII
InChI=1S/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30)
N Key: ZKUCFFYOQOJLGT-UHFFFAOYSA-N
N InChI=1/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30)
Key: ZKUCFFYOQOJLGT-UHFFFAOYAX
CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3=CC=C(C=C3)OCC(=O)NC4=CC=C(C=C4)C(=O)C
Properties
C27 H29 N5 O5
Molar mass
503.56
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
MRS-1706 is a selective
inverse agonist for the
adenosine
A2B
receptor .
[1] It inhibits release of
interleukins and has an antiinflammatory effect.
[2]
[3]
References
^ Li Q, Ye K, Blad CC, den Dulk H, Brouwer J, Ijzerman AP, Beukers MW (February 2007). "ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor". The Journal of Pharmacology and Experimental Therapeutics . 320 (2): 637–45.
doi :
10.1124/jpet.106.111203 .
PMID
17077318 .
^ Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D (May 2008).
"Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study" . Journal of Neurochemistry . 105 (3): 904–9.
doi :
10.1111/j.1471-4159.2007.05191.x .
PMID
18088370 .
^ Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, et al. (June 2008).
"Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells" . Journal of Immunology . 180 (11): 7212–20.
doi :
10.4049/jimmunol.180.11.7212 .
PMC
3628765 .
PMID
18490720 .