From Wikipedia, the free encyclopedia
Chemical compound
ATL-444
(1S ,3R )-1-[2-(6-amino-9-prop-2-ynylpurin-2-yl)ethynyl]-3-methylcyclohexan-1-ol
CAS Number
PubChem
CID
ChemSpider
UNII
CompTox Dashboard (
EPA )
Formula C 17 H 19 N 5 O
Molar mass 309.373 g·mol−1 3D model (
JSmol )
C#CCN1C=NC2=C1N=C(C#C[C@@]3(CCC[C@H](C3)C)O)N=C2N
InChI=1S/C17H19N5O/c1-3-9-22-11-19-14-15(18)20-13(21-16(14)22)6-8-17(23)7-4-5-12(2)10-17/h1,11-12,23H,4-5,7,9-10H2,2H3,(H2,18,20,21)/t12-,17-/m1/s1
Key:VEJLEEFUXFQSHP-SJKOYZFVSA-N
ATL-444 is a
drug which acts as a
potent and reasonably selective
antagonist for the
adenosine
receptors
A1 and
A2A . It has been used to study the role of the adenosine receptor system in the reinforcing action of
cocaine ,
[1] as well as the development of some
cancers .
[2]
See also
References
^ Doyle SE, Breslin FJ, Rieger JM, Beauglehole A, Lynch WJ (August 2012).
"Time and sex-dependent effects of an adenosine A2A/A1 receptor antagonist on motivation to self-administer cocaine in rats" . Pharmacology, Biochemistry, and Behavior . 102 (2): 257–63.
doi :
10.1016/j.pbb.2012.05.001 .
PMC
3383440 .
PMID
22579716 .
^ Choi MS, Moon SM, Lee SA, Park BR, Kim JS, Kim DK, Kim YH, Kim CS (May 2018).
"Adenosine induces intrinsic apoptosis via the PI3K/Akt/mTOR signaling pathway in human pharyngeal squamous carcinoma FaDu cells" . Oncology Letters . 15 (5): 6489–6496.
doi :
10.3892/ol.2018.8089 .
PMC
5876434 .
PMID
29616118 .