LY-379,268 is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (
mGluR2/3).
^Monn JA, Valli MJ, Massey SM, Hansen MM, Kress TJ, Wepsiec JP, et al. (March 1999). "Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors". Journal of Medicinal Chemistry. 42 (6): 1027–1040.
doi:
10.1021/jm980616n.
PMID10090786.
^Rorick-Kehn LM, Johnson BG, Burkey JL, Wright RA, Calligaro DO, Marek GJ, et al. (April 2007). "Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039)". The Journal of Pharmacology and Experimental Therapeutics. 321 (1): 308–317.
doi:
10.1124/jpet.106.110809.
PMID17204749.
S2CID23666836.
^Cai Z, Xiao F, Fratkin JD, Rhodes PG (December 1999). "Protection of neonatal rat brain from hypoxic-ischemic injury by LY379268, a Group II metabotropic glutamate receptor agonist". NeuroReport. 10 (18): 3927–3931.
doi:
10.1097/00001756-199912160-00037.
PMID10716235.
^Moldrich RX, Jeffrey M, Talebi A, Beart PM, Chapman AG, Meldrum BS (July 2001). "Anti-epileptic activity of group II metabotropic glutamate receptor agonists (--)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (--)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795)". Neuropharmacology. 41 (1): 8–18.
doi:
10.1016/S0028-3908(01)00044-2.
PMID11445181.
S2CID26104177.
^Uys JD, LaLumiere RT (November 2008). "Glutamate: the new frontier in pharmacotherapy for cocaine addiction". CNS & Neurological Disorders Drug Targets. 7 (5): 482–491.
doi:
10.2174/187152708786927868.
PMID19128205.
^Cartmell J, Monn JA, Schoepp DD (March 2000). "Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine". Psychopharmacology. 148 (4): 423–429.
doi:
10.1007/s002130050072.
PMID10928316.
S2CID22988081.
^Greenslade RG, Mitchell SN (July 2004). "Selective action of (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), a group II metabotropic glutamate receptor agonist, on basal and phencyclidine-induced dopamine release in the nucleus accumbens shell". Neuropharmacology. 47 (1): 1–8.
doi:
10.1016/j.neuropharm.2004.02.015.
PMID15165829.
S2CID25267021.
^Kłodzinska A, Bijak M, Tokarski K, Pilc A (September 2002). "Group II mGlu receptor agonists inhibit behavioural and electrophysiological effects of DOI in mice". Pharmacology, Biochemistry, and Behavior. 73 (2): 327–332.
doi:
10.1016/S0091-3057(02)00845-6.
PMID12117586.
S2CID28841684.
^Molinaro G, Traficante A, Riozzi B, Di Menna L, Curto M, Pallottino S, et al. (August 2009). "Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice". Molecular Pharmacology. 76 (2): 379–387.
doi:
10.1124/mol.109.056580.
PMID19439499.
S2CID14722003.
^Carter K, Dickerson J, Schoepp DD, Reilly M, Herring N, Williams J, et al. (December 2004). "The mGlu2/3 receptor agonist LY379268 injected into cortex or thalamus decreases neuronal injury in retrosplenial cortex produced by NMDA receptor antagonist MK-801: possible implications for psychosis". Neuropharmacology. 47 (8): 1135–1145.
doi:
10.1016/j.neuropharm.2004.08.018.
PMID15567423.
S2CID22374384.
^Seeman P, Guan HC (November 2008). "Phencyclidine and glutamate agonist LY379268 stimulate dopamine D2High receptors: D2 basis for schizophrenia". Synapse. 62 (11): 819–828.
doi:
10.1002/syn.20561.
PMID18720422.
S2CID206519749.
^Fell MJ, Perry KW, Falcone JF, Johnson BG, Barth VN, Rash KS, et al. (December 2009). "In vitro and in vivo evidence for a lack of interaction with dopamine D2 receptors by the metabotropic glutamate 2/3 receptor agonists 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-bicaroxylate monohydrate (LY354740) and (-)-2-oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic acid (LY379268)". The Journal of Pharmacology and Experimental Therapeutics. 331 (3): 1126–1136.
doi:
10.1124/jpet.109.160598.
PMID19755662.
S2CID23981819.