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Chemical compound
Ro01-6128 is a drug used in scientific research, which acts as a selective
positive allosteric modulator for the
metabotropic glutamate receptor subtype
mGluR1 .
[1]
[2]
[3] It was derived by modification of a
lead compound found via
high-throughput screening , and was further developed to give the improved compound
Ro67-4853 .
[4]
References
^ Knoflach F, Mutel V, Jolidon S, Kew JN, Malherbe P, Vieira E, Wichmann J, Kemp JA (November 2001).
"Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site" . Proceedings of the National Academy of Sciences of the United States of America . 98 (23): 13402–7.
Bibcode :
2001PNAS...9813402K .
doi :
10.1073/pnas.231358298 .
PMC
60883 .
PMID
11606768 .
^ Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ (August 2006). "A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators". Molecular Pharmacology . 70 (2): 616–26.
doi :
10.1124/mol.105.021857 .
PMID
16645124 .
S2CID
2719603 .
^ Sheffler DJ, Conn PJ (September 2008).
"Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells" . Neuropharmacology . 55 (4): 419–27.
doi :
10.1016/j.neuropharm.2008.06.047 .
PMC
2600811 .
PMID
18625258 .
^ Wichmann J, Bleicher K, Vieira E, Woltering T, Knoflach F, Mutel V (December 2002). "Alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates as positive allosteric modulators of mGlu1 receptors". Farmaco . 57 (12): 989–92.
doi :
10.1016/s0014-827x(02)01283-1 .
PMID
12564473 .
Group I
mGluR1 Tooltip Metabotropic glutamate receptor 1
mGluR5 Tooltip Metabotropic glutamate receptor 5
Group II
mGluR2 Tooltip Metabotropic glutamate receptor 2
mGluR3 Tooltip Metabotropic glutamate receptor 3
Group III
mGluR4 Tooltip Metabotropic glutamate receptor 4
mGluR6 Tooltip Metabotropic glutamate receptor 6
mGluR7 Tooltip Metabotropic glutamate receptor 7
mGluR8 Tooltip Metabotropic glutamate receptor 8