From Wikipedia, the free encyclopedia
Chemical compound
Decoglurant
|
|
ATC code | |
---|
|
Legal status |
|
---|
|
5-({7-(Trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}ethynyl)-2-pyridinamine
|
CAS Number | |
---|
PubChem
CID | |
---|
ChemSpider | |
---|
UNII | |
---|
KEGG | |
---|
CompTox Dashboard (
EPA) | |
---|
|
Formula | C21H11F6N5 |
---|
Molar mass | 447.344 g·mol−1 |
---|
3D model (
JSmol) | |
---|
C1=CC(=CC=C1C2=NC3=C(C=NN3C(=C2)C(F)(F)F)C#CC4=CN=C(C=C4)N)C(F)(F)F
|
InChI=1S/C21H11F6N5/c22-20(23,24)15-6-4-13(5-7-15)16-9-17(21(25,26)27)32-19(31-16)14(11-30-32)3-1-12-2-8-18(28)29-10-12/h2,4-11H,(H2,28,29) Key:DMJHZVARRXJSEG-UHFFFAOYSA-N
|
Decoglurant (
INN) (code name RG1578, RO4995819) is a
negative allosteric modulator of the
mGlu2 and
mGlu3 receptors which was under development by
Roche for the
adjunctive treatment of
major depressive disorder.
[1]
[2] Decoglurant progressed as far as
phase II
clinical trials
[1]
[2] but was ultimately discontinued from further development due to disappointing efficacy results.
[3]
[4]
See also
References
External links
|
---|
Group I |
mGluR1Tooltip Metabotropic glutamate receptor 1 | |
---|
mGluR5Tooltip Metabotropic glutamate receptor 5 | |
---|
|
---|
Group II |
mGluR2Tooltip Metabotropic glutamate receptor 2 | |
---|
mGluR3Tooltip Metabotropic glutamate receptor 3 | |
---|
|
---|
Group III |
mGluR4Tooltip Metabotropic glutamate receptor 4 | |
---|
mGluR6Tooltip Metabotropic glutamate receptor 6 | |
---|
mGluR7Tooltip Metabotropic glutamate receptor 7 | |
---|
mGluR8Tooltip Metabotropic glutamate receptor 8 | |
---|
|
---|
|