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Chemical compound
ADX71743
6-(2,4-dimethylphenyl)-2-ethyl-4,5,6,7-tetrahydro-1,3-benzoxazol-4-one
CAS Number
PubChem
CID
IUPHAR/BPS
ChemSpider
ChEMBL
Formula C 17 H 19 N O 2
Molar mass 269.344 g·mol−1 3D model (
JSmol )
CCC1=NC2=C(O1)CC(CC2=O)C3=C(C=C(C=C3)C)C
InChI=1S/C17H19NO2/c1-4-16-18-17-14(19)8-12(9-15(17)20-16)13-6-5-10(2)7-11(13)3/h5-7,12H,4,8-9H2,1-3H3
Key:CPKZCQHJDFSOJT-UHFFFAOYSA-N
ADX71743 is a drug which acts as a potent and selective
negative allosteric modulator of the
metabotropic glutamate receptor 7 .
[1] Few selective ligands are available for this receptor, and so ADX71743 has played an important role into scientific research into the role of this receptor in various processes such as
memory formation,
nociception ,
absence seizures and
psychosis .
[2]
[3]
[4]
[5]
References
^ Kalinichev M, Rouillier M, Girard F, Royer-Urios I, Bournique B, Finn T, et al. (March 2013). "ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization". The Journal of Pharmacology and Experimental Therapeutics . 344 (3): 624–636.
doi :
10.1124/jpet.112.200915 .
PMID
23257312 .
S2CID
5774001 .
^ Klar R, Walker AG, Ghose D, Grueter BA, Engers DW, Hopkins CR, et al. (May 2015).
"Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus" . The Journal of Neuroscience . 35 (19): 7600–7615.
doi :
10.1523/JNEUROSCI.4543-14.2015 .
PMC
4429158 .
PMID
25972184 .
^ Moloney RD, Golubeva AV, O'Connor RM, Kalinichev M, Dinan TG, Cryan JF (2015).
"Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain" . Neurobiology of Stress . 2 : 28–33.
doi :
10.1016/j.ynstr.2015.04.001 .
PMC
4721404 .
PMID
26844237 .
^ Tassin V, Girard B, Chotte A, Fontanaud P, Rigault D, Kalinichev M, et al. (2016).
"Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network" . Frontiers in Neural Circuits . 10 : 31.
doi :
10.3389/fncir.2016.00031 .
PMC
4842779 .
PMID
27199672 .
^ Cieślik P, Woźniak M, Kaczorowska K, Brański P, Burnat G, Chocyk A, et al. (2018).
"Negative Allosteric Modulators of mGlu7 Receptor as Putative Antipsychotic Drugs" . Frontiers in Molecular Neuroscience . 11 : 316.
doi :
10.3389/fnmol.2018.00316 .
PMC
6158327 .
PMID
30294258 .
Group I
mGluR1 Tooltip Metabotropic glutamate receptor 1
mGluR5 Tooltip Metabotropic glutamate receptor 5
Group II
mGluR2 Tooltip Metabotropic glutamate receptor 2
mGluR3 Tooltip Metabotropic glutamate receptor 3
Group III
mGluR4 Tooltip Metabotropic glutamate receptor 4
mGluR6 Tooltip Metabotropic glutamate receptor 6
mGluR7 Tooltip Metabotropic glutamate receptor 7
mGluR8 Tooltip Metabotropic glutamate receptor 8