From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Leucine-rich repeat-containing G-protein coupled receptor 6 is a
protein that in humans is encoded by the LGR6
gene .
[5]
[6] Along with the other
G-protein coupled receptors
LGR4 and
LGR5 , LGR6 is a
Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in
squamous cell carcinoma in mice in vivo.
[7]
This gene encodes a member of the
leucine-rich repeat -containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a
glycoprotein hormone receptor with a large
N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for
ligand binding. Alternative splicing of this gene results in multiple
transcript variants .
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000133067 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000042793 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M, Hsueh AJ (Jan 2001).
"The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7" . Mol Endocrinol . 14 (8): 1257–71.
doi :
10.1210/me.14.8.1257 .
PMID
10935549 .
^
a
b
"Entrez Gene: LGR6 leucine-rich repeat-containing G protein-coupled receptor 6" .
^ Huang, Phillips Y.; Kandyba, Eve; Jabouille, Arnaud; Sjolund, Jonas; Kumar, Atul; Halliwill, Kyle; McCreery, Melissa; DelRosario, Reyno; Kang, Hio Chung (2017).
"Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma" . Nature Genetics . 49 (11): 1624–1632.
doi :
10.1038/ng.3957 .
PMC
5662105 .
PMID
28945253 .
Further reading
Bonaldo MF, Lennon G, Soares MB (1997).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett . 520 (1–3): 97–101.
doi :
10.1016/S0014-5793(02)02775-8 .
PMID
12044878 .
S2CID
7116392 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Clark HF, Gurney AL, Abaya E, et al. (2003).
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70.
doi :
10.1101/gr.1293003 .
PMC
403697 .
PMID
12975309 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Gregory SG, Barlow KF, McLay KE, et al. (2006).
"The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21.
Bibcode :
2006Natur.441..315G .
doi :
10.1038/nature04727 .
PMID
16710414 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .