Complement component 5a receptor 2 is a
protein of the
complement system that in humans is encoded by the C5AR2gene.[5][6] It is highly expressed in the blood and spleen,[7] predominantly by
myeloid cells.[8][9]
C5aR2 was initially thought be a
decoy receptor, acting as a sink for C5a to negatively regulate C5aR1 function.[11] However, more recent research has uncovered independent roles for C5aR2, including modulation of the innate immune response in myeloid cells,[12][13] translocation of C5a to drive
transendothelial migration of
neutrophils,[14]β-arrestin recruitment and modulation of
ERK signalling[15][16] and modulation of
lipid metabolism in
obesity through
C3a-desArg binding.[17] C5aR2 has been implicated in a broad range of inflammatory and infectious diseases.[18][19]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ohno M, Hirata T, Enomoto M, Araki T, Ishimaru H, Takahashi TA (June 2000). "A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells". Molecular Immunology. 37 (8): 407–412.
doi:
10.1016/S0161-5890(00)00067-5.
PMID11090875.
^Li XX, Clark RJ, Woodruff TM (August 2020). "C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages". Journal of Immunology. 205 (4): 1102–1112.
doi:
10.4049/jimmunol.2000407.
PMID32611725.