Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a
protein which in humans is encoded by the EBI3gene.[5][6]
Function
This gene was identified by the induction of its expression in
B lymphocytes by
Epstein–Barr virus infection. The protein encoded by this gene is a secreted
glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (
IL-12). It plays a role in regulating cell-mediated immune responses.[7]
EBI3 is a subunit in 2 distinct
heterodimericcytokines: interleukin-27 (
IL27) and
IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in
T cells,
B cells, and
myeloid cells.[8] IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of
IL12.[7][9]
^
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^Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N (September 2006). "Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells". Nat. Immunol. 7 (9): 929–36.
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Larousserie F, Pflanz S, Coulomb-L'Herminé A, et al. (2004). "Expression of IL-27 in human Th1-associated granulomatous diseases". J. Pathol. 202 (2): 164–71.
doi:
10.1002/path.1508.
PMID14743498.
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Gehlert T, Devergne O, Niedobitek G (2004). "Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease". J. Med. Virol. 73 (3): 432–8.
doi:
10.1002/jmv.20109.
PMID15170639.
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