From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
EPHA3
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
2GSF ,
2QO7 ,
2QO9 ,
2QOB ,
2QOC ,
2QOD ,
2QOF ,
2QOI ,
2QOK ,
2QOL ,
2QON ,
2QOO ,
2QOQ ,
3DZQ ,
3FXX ,
3FY2 ,
4G2F ,
4GK2 ,
4GK3 ,
4GK4 ,
4L0P ,
4P4C ,
4P5Q ,
4P5Z ,
4TWN ,
4TWO
Identifiers
Aliases
EPHA3 , Epha3, AW492086, Cek4, ETK1, End3, Hek, Hek4, Mek4, Tyro4, EK4, ETK, EPH receptor A3, HEK, HEK4, TYRO4External IDs
OMIM :
179611 ;
MGI :
99612 ;
HomoloGene :
21083 ;
GeneCards :
EPHA3 ;
OMA :
EPHA3 - orthologs
Wikidata
EPH receptor A3 (ephrin type-A receptor 3 ) is a
protein that in humans is encoded by the EPHA3
gene .
[5]
[6]
[7]
Function
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.
[7]
Interactions
EPH receptor A3 has been shown to
interact with
EFNB2
[8]
[9] and
EFNA5 .
[9]
[10]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000044524 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000052504 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Boyd AW, Ward LD, Wicks IP, Simpson RJ, Salvaris E, Wilks A, Welch K, Loudovaris M, Rockman S, Busmanis I (March 1992).
"Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line" . J Biol Chem . 267 (5): 3262–7.
doi :
10.1016/S0021-9258(19)50725-6 .
PMID
1737782 .
^ Wicks IP, Wilkinson D, Salvaris E, Boyd AW (April 1992).
"Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines" . Proc Natl Acad Sci U S A . 89 (5): 1611–5.
Bibcode :
1992PNAS...89.1611W .
doi :
10.1073/pnas.89.5.1611 .
PMC
48502 .
PMID
1311845 .
^
a
b
"Entrez Gene: EPHA3 EPH receptor A3" .
^ Cerretti DP, Vanden Bos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E, Park LS, Lyman SD, Copeland NG, Gilbert DJ (November 1995).
"Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases" . Mol. Immunol . 32 (16): 1197–205.
doi :
10.1016/0161-5890(95)00108-5 .
PMID
8559144 .
^
a
b Lackmann M, Mann RJ, Kravets L, Smith FM, Bucci TA, Maxwell KF, Howlett GJ, Olsson JE, Vanden Bos T, Cerretti DP, Boyd AW (June 1997).
"Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor" . J. Biol. Chem . 272 (26): 16521–30.
doi :
10.1074/jbc.272.26.16521 .
PMID
9195962 .
^ Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK (August 1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain". Cytokine . 9 (8): 540–9.
doi :
10.1006/cyto.1997.0199 .
PMID
9245480 .
Further reading
Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci . 21 : 309–45.
doi :
10.1146/annurev.neuro.21.1.309 .
PMID
9530499 .
Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther . 77 (3): 151–81.
doi :
10.1016/S0163-7258(97)00112-5 .
PMID
9576626 .
Ernst AF, Jurney WM, McLoon SC (1999). "Mechanisms involved in development of retinotectal connections: roles of Eph receptor tyrosine kinases, NMDA receptors and nitric oxide". Prog. Brain Res . 118 : 115–31.
doi :
10.1016/S0079-6123(08)63204-5 .
PMID
9932438 .
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development . 126 (10): 2033–44.
doi :
10.1242/dev.126.10.2033 .
PMID
10207129 .
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol . International Review of Cytology. 196 : 177–244.
doi :
10.1016/S0074-7696(00)96005-4 .
ISBN
9780123646002 .
PMID
10730216 .
Xu Q, Mellitzer G, Wilkinson DG (2001).
"Roles of Eph receptors and ephrins in segmental patterning" . Philos. Trans. R. Soc. Lond. B Biol. Sci . 355 (1399): 993–1002.
doi :
10.1098/rstb.2000.0635 .
PMC
1692797 .
PMID
11128993 .
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci . 2 (3): 155–64.
doi :
10.1038/35058515 .
PMID
11256076 .
S2CID
205014301 .
Beckmann MP, Cerretti DP, Baum P, Vanden Bos T, James L, Farrah T, Kozlosky C, Hollingsworth T, Shilling H, Maraskovsky E (1994).
"Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors" . EMBO J . 13 (16): 3757–62.
doi :
10.1002/j.1460-2075.1994.tb06685.x .
PMC
395287 .
PMID
8070404 .
Wicks IP, Lapsys NM, Baker E, Campbell LJ, Boyd AW,
Sutherland GR (1994). "Localization of a human receptor tyrosine kinase (ETK1) to chromosome region 3p11.2". Genomics . 19 (1): 38–41.
doi :
10.1006/geno.1994.1009 .
PMID
8188238 .
Cerretti DP, Vanden Bos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E, Park LS, Lyman SD, Copeland NG, Gilbert DJ (1996).
"Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases" . Mol. Immunol . 32 (16): 1197–205.
doi :
10.1016/0161-5890(95)00108-5 .
PMID
8559144 .
Lackmann M, Mann RJ, Kravets L, Smith FM, Bucci TA, Maxwell KF, Howlett GJ, Olsson JE, Vanden Bos T, Cerretti DP, Boyd AW (1997).
"Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor" . J. Biol. Chem . 272 (26): 16521–30.
doi :
10.1074/jbc.272.26.16521 .
PMID
9195962 .
Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK (1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain". Cytokine . 9 (8): 540–9.
doi :
10.1006/cyto.1997.0199 .
PMID
9245480 .
Ephnomenclaturecommittee (1997).
"Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee" . Cell . 90 (3): 403–4.
doi :
10.1016/S0092-8674(00)80500-0 .
PMID
9267020 .
S2CID
26773768 .
Lackmann M, Oates AC, Dottori M, Smith FM, Do C, Power M, Kravets L, Boyd AW (1998).
"Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization" . J. Biol. Chem . 273 (32): 20228–37.
doi :
10.1074/jbc.273.32.20228 .
PMID
9685371 .
Ciossek T, Monschau B, Kremoser C, Löschinger J, Lang S, Müller BK, Bonhoeffer F, Drescher U (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro". Eur. J. Neurosci . 10 (5): 1574–80.
doi :
10.1046/j.1460-9568.1998.00180.x .
PMID
9751130 .
S2CID
20470923 .
Activity Regulation Classification Kinetics Types
Angiopoietin
CNTF
EGF (ErbB)
FGF
FGFR1
FGFR2
Agonists:
Ersofermin
FGF (
1 ,
2 (bFGF) ,
3 ,
4 ,
5 ,
6 ,
7 (
KGF ),
8 ,
9 ,
10 (KGF2) ,
17 ,
18 ,
22 )
Palifermin
Repifermin
Selpercatinib
Sprifermin
Trafermin
FGFR3
FGFR4 Unsorted
HGF (c-Met)
IGF
LNGF (p75NTR )
PDGF
RET (GFL)
SCF (c-Kit)
TGFβ
Trk
TrkA
Negative allosteric modulators:
VM-902A
TrkB
Agonists:
3,7-DHF
3,7,8,2'-THF
4'-DMA-7,8-DHF
7,3'-DHF
7,8-DHF
7,8,2'-THF
7,8,3'-THF
Amitriptyline
BDNF
BNN-20
Deoxygedunin
Deprenyl
Diosmetin
DMAQ-B1
HIOC
LM22A-4
N-Acetylserotonin
NT-3
NT-4
Norwogonin (5,7,8-THF)
R7
R13
TDP6
TrkC
VEGF Others
Additional growth factors:
Adrenomedullin
Colony-stimulating factors (see
here instead)
Connective tissue growth factor (CTGF)
Ephrins (
A1 ,
A2 ,
A3 ,
A4 ,
A5 ,
B1 ,
B2 ,
B3 )
Erythropoietin (see
here instead)
Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
Glia maturation factor (GMF)
Hepatoma-derived growth factor (HDGF)
Interleukins /
T-cell growth factors (see
here instead)
Leukemia inhibitory factor (LIF)
Macrophage-stimulating protein (MSP; HLP, HGFLP)
Midkine (NEGF2)
Migration-stimulating factor (MSF; PRG4)
Oncomodulin
Pituitary adenylate cyclase-activating peptide (PACAP)
Pleiotrophin
Renalase
Thrombopoietin (see
here instead)
Wnt signaling proteins
Additional growth factor receptor modulators:
Cerebrolysin (neurotrophin mixture)