From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Platelet-derived growth factor D is a
protein that in humans is encoded by the PDGFD
gene .
[5]
[6]
[7]
The protein encoded by this gene is a member of the
platelet-derived growth factor family. The four members of this family are
mitogenic factors for cells of
mesenchymal origin and are characterized by a core
motif of eight cysteines, seven of which are found in this factor. This gene product only forms
homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual
N-terminal domain, the
CUB domain . Two splice variants have been identified for this gene.
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000170962 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000032006 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Hamada T, Ui-Tei K, Imaki J, Miyata Y (Feb 2001). "Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein". Biochem Biophys Res Commun . 280 (3): 733–7.
doi :
10.1006/bbrc.2000.4187 .
PMID
11162582 .
^ LaRochelle WJ, Jeffers M, Corvalan JR, Jia XC, Feng X, Vanegas S, Vickroy JD, Yang XD, Chen F, Gazit G, Mayotte J, Macaluso J, Rittman B, Wu F, Dhanabal M, Herrmann J, Lichenstein HS (Apr 2002). "Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer". Cancer Res . 62 (9): 2468–73.
PMID
11980634 .
^
a
b
"Entrez Gene: PDGFD platelet derived growth factor D" .
Further reading
Bergsten E, Uutela M, Li X, et al. (2001). "PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor". Nat. Cell Biol . 3 (5): 512–6.
doi :
10.1038/35074588 .
PMID
11331881 .
S2CID
25074372 .
LaRochelle WJ, Jeffers M, McDonald WF, et al. (2001). "PDGF-D, a new protease-activated growth factor". Nat. Cell Biol . 3 (5): 517–21.
doi :
10.1038/35074593 .
PMID
11331882 .
S2CID
19633551 .
Uutela M, Laurén J, Bergsten E, et al. (2001).
"Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes" . Circulation . 103 (18): 2242–7.
doi :
10.1161/01.cir.103.18.2242 .
PMID
11342471 .
Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis . 8 : 185–95.
PMID
12107412 .
Changsirikulchai S, Hudkins KL, Goodpaster TA, et al. (2003).
"Platelet-derived growth factor-D expression in developing and mature human kidneys" . Kidney Int . 62 (6): 2043–54.
doi :
10.1046/j.1523-1755.2002.00662.x .
PMID
12427128 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Clark HF, Gurney AL, Abaya E, et al. (2003).
"The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70.
doi :
10.1101/gr.1293003 .
PMC
403697 .
PMID
12975309 .
Taneda S, Hudkins KL, Topouzis S, et al. (2004).
"Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury" . J. Am. Soc. Nephrol . 14 (10): 2544–55.
doi :
10.1097/01.ASN.0000089828.73014.C8 .
PMID
14514732 .
Uutela M, Wirzenius M, Paavonen K, et al. (2004).
"PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis" . Blood . 104 (10): 3198–204.
doi :
10.1182/blood-2004-04-1485 .
PMID
15271796 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Ray S, Gao C, Wyatt K, et al. (2005).
"Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation" . J. Biol. Chem . 280 (9): 8494–502.
doi :
10.1074/jbc.M413570200 .
PMID
15611105 .
Ustach CV, Kim HR (2005).
"Platelet-Derived Growth Factor D Is Activated by Urokinase Plasminogen Activator in Prostate Carcinoma Cells" . Mol. Cell. Biol . 25 (14): 6279–88.
doi :
10.1128/MCB.25.14.6279-6288.2005 .
PMC
1168822 .
PMID
15988036 .
Liu MY, Eyries M, Zhang C, et al. (2006).
"Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1" . Blood . 107 (6): 2322–9.
doi :
10.1182/blood-2005-06-2377 .
PMID
16189269 .
Angiopoietin
CNTF
EGF (ErbB)
FGF
FGFR1
FGFR2
Agonists:
Ersofermin
FGF (
1 ,
2 (bFGF) ,
3 ,
4 ,
5 ,
6 ,
7 (
KGF ),
8 ,
9 ,
10 (KGF2) ,
17 ,
18 ,
22 )
Palifermin
Repifermin
Selpercatinib
Sprifermin
Trafermin
FGFR3
FGFR4 Unsorted
HGF (c-Met)
IGF
LNGF (p75NTR )
PDGF
RET (GFL)
SCF (c-Kit)
TGFβ
Trk
TrkA
Negative allosteric modulators:
VM-902A
TrkB
Agonists:
3,7-DHF
3,7,8,2'-THF
4'-DMA-7,8-DHF
7,3'-DHF
7,8-DHF
7,8,2'-THF
7,8,3'-THF
Amitriptyline
BDNF
BNN-20
Deoxygedunin
Deprenyl
Diosmetin
DMAQ-B1
HIOC
LM22A-4
N-Acetylserotonin
NT-3
NT-4
Norwogonin (5,7,8-THF)
R7
R13
TDP6
TrkC
VEGF Others
Additional growth factors:
Adrenomedullin
Colony-stimulating factors (see
here instead)
Connective tissue growth factor (CTGF)
Ephrins (
A1 ,
A2 ,
A3 ,
A4 ,
A5 ,
B1 ,
B2 ,
B3 )
Erythropoietin (see
here instead)
Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
Glia maturation factor (GMF)
Hepatoma-derived growth factor (HDGF)
Interleukins /
T-cell growth factors (see
here instead)
Leukemia inhibitory factor (LIF)
Macrophage-stimulating protein (MSP; HLP, HGFLP)
Midkine (NEGF2)
Migration-stimulating factor (MSF; PRG4)
Oncomodulin
Pituitary adenylate cyclase-activating peptide (PACAP)
Pleiotrophin
Renalase
Thrombopoietin (see
here instead)
Wnt signaling proteins
Additional growth factor receptor modulators:
Cerebrolysin (neurotrophin mixture)