From Wikipedia, the free encyclopedia
Class of enzymes
The enzyme α-N -acetylglucosaminidase (
EC
3.2.1.50 , α-acetylglucosaminidase , N-acetyl-α-D-glucosaminidase , N-acetyl-α-glucosaminidase , α-D-2-acetamido-2-deoxyglucosidase ) is a
protein associated with
Sanfilippo syndrome , with
systematic name α-N -acetyl-D -glucosaminide N -acetylglucosaminohydrolase.
[2]
[3]
[4]
[5] It
catalyses the
hydrolysis of terminal non-reducing N -acetyl-D -glucosamine residues in N -acetyl-α-D -glucosaminides, and also
UDP-N -acetylglucosamine .
References
^ Birrane, Gabriel; Dassier, Anne-Laure; Romashko, Alla; Lundberg, Dianna; Holmes, Kevin; Cottle, Thomas; Norton, Angela W.; Zhang, Bohong; Concino, Michael F.; Meiyappan, Muthuraman (2019).
"Structural characterization of the α-N -acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B" . Journal of Structural Biology . 205 (3): 65–71.
doi :
10.1016/j.jsb.2019.02.005 .
PMID
30802506 .
S2CID
73482664 .
^ von Figura K (November 1977).
"Human α-N -acetylglucosaminidase. 1. Purification and properties" . European Journal of Biochemistry . 80 (2): 523–533.
doi :
10.1111/j.1432-1033.1977.tb11908.x .
PMID
411658 .
^ von Figura K (November 1977).
"Human α-N -acetylglucosaminidase. 2. Activity towards natural substrates and multiple recognition forms" . European Journal of Biochemistry . 80 (2): 535–542.
doi :
10.1111/j.1432-1033.1977.tb11909.x .
PMID
923593 .
^ Weissmann B, Rowin G, Marshall J, Friederici D (January 1967). "Mammalian α-acetylglucosaminidase. Enzymic properties, tissue distribution, and intracellular localization". Biochemistry . 6 (1): 207–214.
doi :
10.1021/bi00853a033 .
PMID
4291567 .
^ Werries E, Wollek E, Gottschalk A, Buddecke E (October 1969).
"Separation of N -acetyl-α-glucosaminidase and N -acetyl-α-galactosaminidase from ox spleen. Cleavage of the O-glycosidic linkage between carbohydrate and polypeptide in ovine and bovine submaxillary glycoprotein by N -acetyl-α-galactosaminidase" . European Journal of Biochemistry . 10 (3): 445–449.
doi :
10.1111/j.1432-1033.1969.tb00709.x .
PMID
5348072 .
External links
Activity Regulation Classification Kinetics Types