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Class of enzymes
UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid
decarboxylating) (
EC
1.1.1.305, UDP-GlcUA decarboxylase, ArnADH) is an
enzyme with
systematic name UDP-glucuronate:NAD+ oxidoreductase (decarboxylating).
[1]
[2]
[3]
[4]
[5] This enzyme
catalyses the following
chemical reaction
- UDP-glucuronate + NAD+ UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+
The activity is part of a bifunctional enzyme also performing the reaction of
EC 2.1.2.13 (UDP-4-amino-4-deoxy-L-arabinose formyltransferase).
References
-
^ Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR (April 2005).
"A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose". The Journal of Biological Chemistry. 280 (14): 14154–67.
doi:
10.1074/jbc.M414265200.
PMID
15695810.
-
^ Gatzeva-Topalova PZ, May AP, Sousa MC (October 2004).
"Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance". Biochemistry. 43 (42): 13370–9.
doi:
10.1021/bi048551f.
PMC
2680612.
PMID
15491143.
-
^ Williams GJ, Breazeale SD, Raetz CR, Naismith JH (June 2005).
"Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis". The Journal of Biological Chemistry. 280 (24): 23000–8.
doi:
10.1074/jbc.M501534200.
PMC
3326539.
PMID
15809294.
-
^ Gatzeva-Topalova PZ, May AP, Sousa MC (June 2005).
"Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance". Structure. 13 (6): 929–42.
doi:
10.1016/j.str.2005.03.018.
PMC
2997725.
PMID
15939024.
-
^ Yan A, Guan Z, Raetz CR (December 2007).
"An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli". The Journal of Biological Chemistry. 282 (49): 36077–89.
doi:
10.1074/jbc.M706172200.
PMC
2613183.
PMID
17928292.
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