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Class of enzymes
UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase (
EC
1.1.1.335, WlbA, WbpB) is an
enzyme with
systematic name UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate:NAD+ 3-oxidoreductase.
[1]
[2]
[3]
[4] This enzyme
catalyses the following
chemical reaction:
- UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate + NAD+
UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + NADH + H+
This enzyme participates in the biosynthesis of
lipopolysaccharide UDP-alpha-D-ManNAc3NAcA.
References
-
^ Westman EL, McNally DJ, Charchoglyan A, Brewer D, Field RA, Lam JS (May 2009).
"Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa". The Journal of Biological Chemistry. 284 (18): 11854–62.
doi:
10.1074/jbc.M808583200.
PMC
2673254.
PMID
19282284.
-
^ Larkin A, Imperiali B (June 2009).
"Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1". Biochemistry. 48 (23): 5446–55.
doi:
10.1021/bi900186u.
PMC
2694220.
PMID
19348502.
-
^ Thoden JB, Holden HM (September 2010).
"Structural and functional studies of WlbA: A dehydrogenase involved in the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid". Biochemistry. 49 (36): 7939–48.
doi:
10.1021/bi101103s.
PMC
4241754.
PMID
20690587.
-
^ Thoden JB, Holden HM (March 2011).
"Biochemical and structural characterization of WlbA from Bordetella pertussis and Chromobacterium violaceum: enzymes required for the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid". Biochemistry. 50 (9): 1483–91.
doi:
10.1021/bi101871f.
PMC
3050068.
PMID
21241053.
External links
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