From Wikipedia, the free encyclopedia
Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming) (
EC
1.1.1.325) is an
enzyme with
systematic name L-threo-7,8-dihydrobiopterin:NADP+ oxidoreductase.
[1]
[2] This enzyme
catalyses the following
chemical reaction
- (1) L-threo-7,8-dihydrobiopterin + NADP+
sepiapterin + NADPH + H+
- (2) L-threo-tetrahydrobiopterin + 2 NADP+
6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H+
This bacterial (
Chlorobium tepidum) enzyme catalyses the final step in the
de novo synthesis of
tetrahydrobiopterin from GTP.
References
-
^ Cho SH, Na JU, Youn H, Hwang CS, Lee CH, Kang SO (June 1999).
"Sepiapterin reductase producing L-threo-dihydrobiopterin from Chlorobium tepidum". The Biochemical Journal. 340 ( Pt 2): 497–503.
doi:
10.1042/0264-6021:3400497.
PMC
1220277.
PMID
10333495.
-
^ Supangat S, Choi YK, Park YS, Son D, Han CD, Lee KH (February 2005).
"Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum". Acta Crystallographica Section F. 61 (Pt 2): 202–4.
doi:
10.1107/S174430910403444X.
PMC
1952253.
PMID
16510994.
External links
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