From Wikipedia, the free encyclopedia
Chemical compound
Selurampanel
ATC code
N -[7-Isopropyl-6-(2-methylpyrazol-3-yl)-2,4-dioxo-1H -quinazolin-3-yl]methanesulfonamide
CAS Number
PubChem
CID
ChemSpider
UNII
CompTox Dashboard (
EPA )
Formula C 16 H 19 N 5 O 4 S
Molar mass 377.42 g·mol−1 3D model (
JSmol )
CC(C)c1cc2c(cc1c3ccnn3C)c(=O)n(c(=O)[nH]2)NS(=O)(=O)C
InChI=1S/C16H19N5O4S/c1-9(2)10-8-13-12(7-11(10)14-5-6-17-20(14)3)15(22)21(16(23)18-13)19-26(4,24)25/h5-9,19H,1-4H3,(H,18,23)
Key:MCECSFFXUPEPDB-UHFFFAOYSA-N
Selurampanel (
INN , code name BGG492 ) is a
drug closely related to the
quinoxalinedione series which acts as a
competitive antagonist of the
AMPA and
kainate receptors and, as of 2015, is being investigated in
clinical trials by
Novartis for the treatment of
epilepsy .
[1]
[2]
[3] It has also been studied in the acute treatment of
migraine , and was found to produce some pain relief, but with a relatively high rate of
side effects .
[4]
References
^ Faught E (January 2014). "BGG492 (selurampanel), an AMPA/kainate receptor antagonist drug for epilepsy". Expert Opinion on Investigational Drugs . 23 (1): 107–113.
doi :
10.1517/13543784.2014.848854 .
PMID
24147649 .
S2CID
40105670 .
^ Belcastro V, Verrotti A (2015). "Novel Molecular Targets for Drug-Treatment of Epilepsy". In Striano P (ed.). Epilepsy Towards the Next Decade . Contemporary Clinical Neuroscience. pp. 183–199.
doi :
10.1007/978-3-319-12283-0_10 .
ISBN
978-3-319-12282-3 .
^ Hanada T (2014).
"The AMPA receptor as a therapeutic target in epilepsy: preclinical and clinical evidence" . Journal of Receptor, Ligand and Channel Research : 39.
doi :
10.2147/JRLCR.S51475 .
ISSN
1178-699X .
^ Gomez-Mancilla B, Brand R, Jürgens TP, Göbel H, Sommer C, Straube A, et al. (February 2014).
"Randomized, multicenter trial to assess the efficacy, safety and tolerability of a single dose of a novel AMPA receptor antagonist BGG492 for the treatment of acute migraine attacks" . Cephalalgia . 34 (2): 103–113.
doi :
10.1177/0333102413499648 .
PMID
23963355 .
S2CID
206520491 .
AMPAR Tooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KAR Tooltip Kainate receptor
NMDAR Tooltip N-Methyl-D-aspartate receptor