From Wikipedia, the free encyclopedia
Chemical compound
Dasolampanel
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ATC code | |
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(3S,4aS,6S,8aR)-6-(3-Chloro-2-(1H-tetrazol-5-yl)phenoxy)decahydroisoquinoline-3-carboxylic acid
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CAS Number | |
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PubChem
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ChemSpider | |
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KEGG | |
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CompTox Dashboard (
EPA) | |
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Formula | C17H20ClN5O3 |
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Molar mass | 377.83 g·mol−1 |
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3D model (
JSmol) | |
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c1cc(c(c(c1)Cl)c2[nH]nnn2)O[C@H]3CC[C@H]4CN[C@@H](C[C@H]4C3)C(=O)O
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InChI=1S/C17H20ClN5O3/c18-12-2-1-3-14(15(12)16-20-22-23-21-16)26-11-5-4-9-8-19-13(17(24)25)7-10(9)6-11/h1-3,9-11,13,19H,4-8H2,(H,24,25)(H,20,21,22,23)/t9-,10+,11-,13-/m0/s1 Key:LAKQPSQCICNZII-NOHGZBONSA-N
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Dasolampanel (
INN,
USAN, code name NGX-426) is an
orally bioavailable
analog of
tezampanel and thereby
competitive antagonist of the
AMPA and
kainate receptors which was under development by
Raptor Pharmaceuticals/
Torrey Pines Therapeutics for the treatment of
chronic pain conditions including
neuropathic pain and
migraine.
[1] It was developed as a follow-on compound to tezampanel, as tezampanel is not bioavailable orally and must be administered by
intravenous injection,
[2]
[3] but ultimately neither drug was ever marketed.
See also
References
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Monoaminergics | |
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Ion channel blockers |
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Anticonvulsants (e.g.,
gabapentin,
pregabalin,
mirogabalin,
carbamazepine,
oxcarbazepine,
lacosamide,
lamotrigine)
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Local anesthetics (e.g.,
lidocaine)
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Mexiletine
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TCAsTooltip Tricyclic antidepressants (e.g.,
amitriptyline,
nortriptyline,
desipramine)
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Ziconotide
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Others |
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Alpha lipoic acid
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Benfotiamine
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Botulinum toxin A
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Bupropion
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Cannabinoids (e.g.,
cannabis,
dronabinol,
nabilone)
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NMDA receptor antagonists (e.g.,
ketamine,
dextromethorphan,
methadone)
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Opioids (e.g.,
hydrocodone,
morphine,
oxycodone,
methadone,
buprenorphine,
tramadol,
tapentadol)
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Sodium oxybate (
GHB)
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AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor | |
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KARTooltip Kainate receptor | |
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NMDARTooltip N-Methyl-D-aspartate receptor | |
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