Combination of | |
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Amlodipine | Calcium channel blocker |
Benazepril | ACE inhibitor |
Clinical data | |
Trade names | Lotrel |
AHFS/ Drugs.com | Professional Drug Facts |
License data | |
Routes of administration | By mouth |
ATC code | |
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Amlodipine/benazepril, sold under the brand name Lotrel among others, is a fixed-dose combination medication used to treat high blood pressure. [1] It is a combination of amlodipine, as the besilate, a calcium channel blocker, and benazepril, an angiotensin converting enzyme inhibitor. [1] It may be used if a single agent is not sufficient. [1] It is taken by mouth. [1]
Common side effects include cough, dizziness, and swelling. [1] Serious side effects may include angioedema, myocardial infarction, high blood potassium, liver problems, and low blood pressure. [1] Use in pregnancy is not recommended. [1] Amlodipine works by increasing the size of arteries while benazepril works by decreasing renin-angiotensin-aldosterone system activity. [1]
The combination was approved for medical use in the United States in 1995. [2] It is available as a generic medication. [3] In 2021, it was the 150th most commonly prescribed medication in the United States, with more than 3 million prescriptions. [4] [5]
It is used to treat high blood pressure. [1] It is not a first-line treatment. [6]