From Wikipedia, the free encyclopedia
Leukotriene-C4 hydrolase (
EC
3.4.19.14, gamma-glutamyl leukotrienase) is an
enzyme.
[1]
[2]
[3]
[4]
Gamma-glutamyltransferase 5 (GGT5) is a human
gene which encodes an enzyme protein that belongs to this class of enzymes. This enzyme
catalyses the following
chemical reaction
-
leukotriene C4 + H2O
leukotriene D4 + L-
glutamate
The mouse enzyme is specific for leukotriene C4.
References
-
^ Carter BZ, Wiseman AL, Orkiszewski R, Ballard KD, Ou CN, Lieberman MW (May 1997).
"Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice". The Journal of Biological Chemistry. 272 (19): 12305–10.
doi:
10.1074/jbc.272.19.12305.
PMID
9139674.
-
^ Shi ZZ, Han B, Habib GM, Matzuk MM, Lieberman MW (August 2001).
"Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response". Molecular and Cellular Biology. 21 (16): 5389–95.
doi:
10.1128/mcb.21.16.5389-5395.2001.
PMC
87261.
PMID
11463821.
-
^ Han B, Luo G, Shi ZZ, Barrios R, Atwood D, Liu W, Habib GM, Sifers RN, Corry DB, Lieberman MW (August 2002).
"Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo". The American Journal of Pathology. 161 (2): 481–90.
doi:
10.1016/s0002-9440(10)64204-6.
PMC
1850737.
PMID
12163373.
-
^ Wickham S, West MB, Cook PF, Hanigan MH (July 2011).
"Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes". Analytical Biochemistry. 414 (2): 208–14.
doi:
10.1016/j.ab.2011.03.026.
PMC
3099546.
PMID
21447318.
External links
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Receptor (
ligands) |
BLTTooltip Leukotriene B4 receptor |
BLT1Tooltip Leukotriene B4 receptor 1 | |
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BLT2Tooltip Leukotriene B4 receptor 2 | |
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CysLTTooltip Cysteinyl leukotriene receptor |
CysLT1Tooltip Cysteinyl leukotriene receptor 1 | |
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CysLT2Tooltip Cysteinyl leukotriene receptor 2 | |
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CysLTETooltip Cysteinyl leukotriene receptor E | |
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Enzyme (
inhibitors) |
5-LOXTooltip Arachidonate 5-lipoxygenase | |
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12-LOXTooltip Arachidonate 12-lipoxygenase | |
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15-LOXTooltip Arachidonate 15-lipoxygenase | |
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LTA4HTooltip Leukotriene A4 hydrolase | |
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LTB4HTooltip Leukotriene B4 ω-hydroxylase | |
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LTC4STooltip Leukotriene C4 synthase | |
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LTC4HTooltip Leukotriene C4 hydrolase | |
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LTD4Tooltip Leukotriene D4 hydrolase | |
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Others | |
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Activity | |
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Regulation | |
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Classification | |
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Kinetics | |
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Types | |
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