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Glycosyl hydrolase family 66
Identifiers
SymbolGlyco_hydro_66
Pfam PF13199
Pfam clan CL0058
CAZy GH66
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

In molecular biology, glycoside hydrolase family 66 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. [1] [2] [3] This classification is available on the CAZy web site, [4] [5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. [6] [7]

Glycoside hydrolase family 66 CAZY GH_66 includes enzymes with cycloisomaltooligosaccharide glucanotransferase EC 2.4.1.248 and dextranase EC 3.2.1.11 activities. [8] [9]

References

  1. ^ Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G (July 1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America. 92 (15): 7090–4. Bibcode: 1995PNAS...92.7090H. doi: 10.1073/pnas.92.15.7090. PMC  41477. PMID  7624375.
  2. ^ Davies G, Henrissat B (September 1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–9. doi: 10.1016/S0969-2126(01)00220-9. PMID  8535779.
  3. ^ Henrissat B, Bairoch A (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal. 316 (Pt 2): 695–6. doi: 10.1042/bj3160695. PMC  1217404. PMID  8687420.
  4. ^ "Home". CAZy.org. Retrieved 2018-03-06.
  5. ^ Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (Database issue): D490–5. doi: 10.1093/nar/gkt1178. PMC  3965031. PMID  24270786.
  6. ^ "Glycoside Hydrolase Family 66". CAZypedia.org. Retrieved 2018-03-06.
  7. ^ CAZypedia Consortium (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes" (PDF). Glycobiology. 28 (1): 3–8. doi: 10.1093/glycob/cwx089. PMID  29040563.
  8. ^ Igarashi T, Yamamoto A, Goto N (1995). "Sequence analysis of the Streptococcus mutans Ingbritt dexA gene encoding extracellular dextranase". Microbiol Immunol. 39 (11): 853–60. doi: 10.1111/j.1348-0421.1995.tb03282.x. PMID  8657012. S2CID  27770996.
  9. ^ Funane K, Kawabata Y, Suzuki R, Kim YM, Kang HK, Suzuki N, et al. (2011). "Deletion analysis of regions at the C-terminal part of cycloisomaltooligosaccharide glucanotransferase from Bacillus circulans T-3040". Biochim Biophys Acta. 1814 (3): 428–34. doi: 10.1016/j.bbapap.2010.12.009. PMID  21193067.