Glycoside hydrolasesEC3.2.1. are a widespread group of enzymes that
hydrolyse the
glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the
CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]
Glycoside hydrolase family 37
CAZY GH_37 comprises enzymes with only one known activity;
trehalase (
EC3.2.1.28). Trehalase is the enzyme responsible for the degradation of the
disaccharide alpha,alpha-trehalose yielding two
glucose subunits.[8] It is an enzyme found in a wide variety of organisms and whose sequence has been highly conserved throughout evolution.