Glycosyl hydrolases family 35 | |||||||||
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![]() native structure of beta-galactosidase from penicillium sp. | |||||||||
Identifiers | |||||||||
Symbol | Glyco_hydro_35 | ||||||||
Pfam | PF01301 | ||||||||
Pfam clan | CL0058 | ||||||||
InterPro | IPR001944 | ||||||||
PROSITE | PDOC00910 | ||||||||
CAZy | GH35 | ||||||||
Membranome | 788 | ||||||||
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In molecular biology, glycoside hydrolase family 35 is a family of glycoside hydrolases.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. [1] [2] [3] This classification is available on the CAZy web site, [4] [5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. [6] [7]
Glycoside hydrolase family 35 CAZY GH_35 comprises enzymes with only one known activity; beta-galactosidase ( EC 3.2.1.23). Mammalian beta-galactosidase is a lysosomal enzyme (gene GLB1) which cleaves the terminal galactose from gangliosides, glycoproteins, and glycosaminoglycans and whose deficiency is the cause of the genetic disease Gm(1) gangliosidosis ( Morquio disease type B).