From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
GUCY1B1 Identifiers
Aliases
GUCY1B1 , guanylate cyclase 1, soluble, beta 3, GUCSB3, guanylate cyclase 1 soluble subunit beta, GC-SB3, GUC1B3, GC-S-beta-1, guanylate cyclase 1 soluble subunit beta 1, GUCB3, GUCY1B3External IDs
OMIM :
139397 ;
MGI :
1860604 ;
HomoloGene :
664 ;
GeneCards :
GUCY1B1 ;
OMA :
GUCY1B1 - orthologs
RNA expression pattern
Bgee
Human
Mouse (ortholog)
Top expressed in middle temporal gyrus orbitofrontal cortex lateral nuclear group of thalamus superior frontal gyrus Brodmann area 46 postcentral gyrus Brodmann area 23 Pars compacta pons entorhinal cortex
Top expressed in olfactory tubercle habenula lateral septal nucleus anterior amygdaloid area globus pallidus left lung lobe ventromedial nucleus dorsomedial hypothalamic nucleus dorsal tegmental nucleus mammillary body
More reference expression data
BioGPS
Wikidata
Guanylate cyclase soluble subunit beta-1 is an
enzyme that in humans is encoded by the GUCY1B3
gene .
[5]
[6]
Function
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of
GTP to the second messenger
cGMP and functions as the main receptor for
nitric oxide and
nitrovasodilator drugs.
[6]
Interactions
GUCY1B3 has been shown to
interact with
Heat shock protein 90kDa alpha (cytosolic), member A1
[7] and
Endothelial NOS .
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000061918 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000028005 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Giuili G, Scholl U, Bulle F, Guellaën G (Jul 1992).
"Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain" . FEBS Lett . 304 (1): 83–8.
doi :
10.1016/0014-5793(92)80594-7 .
PMID
1352257 .
S2CID
26032197 .
^
a
b
"Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3" .
^
a
b Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (Aug 2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol . 285 (2): H669–78.
doi :
10.1152/ajpheart.01025.2002 .
PMID
12676772 .
Further reading
Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA (2000). "Guanylyl cyclases and signaling by cyclic GMP". Pharmacol. Rev . 52 (3): 375–414.
PMID
10977868 .
Chhajlani V, Frändberg PA, Ahlner J, Axelsson KL, Wikberg JE (1991).
"Heterogeneity in human soluble guanylate cyclase due to alternative splicing" . FEBS Lett . 290 (1–2): 157–8.
doi :
10.1016/0014-5793(91)81248-7 .
PMID
1680753 .
S2CID
35130409 .
Giuili G, Roechel N, Scholl U, Mattei MG, Guellaen G (1993). "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33". Hum. Genet . 91 (3): 257–60.
doi :
10.1007/BF00218267 .
PMID
8097486 .
S2CID
24237232 .
Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD (1996).
"cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue" . J. Cell. Physiol . 167 (2): 213–21.
doi :
10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S .
PMID
8613461 .
S2CID
25406282 .
Zabel U, Weeger M, La M, Schmidt HH (1998).
"Human soluble guanylate cyclase: functional expression and revised isoenzyme family" . Biochem. J . 335 (1): 51–7.
doi :
10.1042/bj3350051 .
PMC
1219751 .
PMID
9742212 .
Russwurm M, Wittau N, Koesling D (2002).
"Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes" . J. Biol. Chem . 276 (48): 44647–52.
doi :
10.1074/jbc.M105587200 .
PMID
11572861 .
Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol . 285 (2): H669–78.
doi :
10.1152/ajpheart.01025.2002 .
PMID
12676772 .
Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S (2005).
"AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase" . J. Biol. Chem . 279 (47): 49346–54.
doi :
10.1074/jbc.M410565200 .
PMID
15381706 .
Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, Zamorano-León JJ, Sacristán D, de Prada TP, Calahorra J, Macaya C, Vela-Navarrete R, López-Farré AJ (2006).
"Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction" . Int. J. Impot. Res . 18 (5): 432–7.
doi :
10.1038/sj.ijir.3901461 .
PMID
16528291 .
Activity Regulation Classification Kinetics Types