From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
ADCY10 Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
4CLK ,
4CLL ,
4CLP ,
4CLS ,
4CLT ,
4CLU ,
4CLW ,
4CLY ,
4CLZ ,
4CM0 ,
4CM2 ,
4OYA ,
4OYB ,
4OYI ,
4OYM ,
4OYO ,
4OYP ,
4OYW ,
4OYX ,
4OYZ ,
4OZ2 ,
4OZ3 ,
4UST ,
4USU ,
4USV ,
4USW ,
5D0R
Identifiers
Aliases
ADCY10 , HCA2, SAC, SACI, Sacy, hsAC, HEL-S-7a, adenylate cyclase 10 (soluble), adenylate cyclase 10, soluble, adenylate cyclase 10External IDs
OMIM :
605205 ;
MGI :
2660854 ;
HomoloGene :
10188 ;
GeneCards :
ADCY10 ;
OMA :
ADCY10 - orthologs
Wikidata
Adenylyl cyclase 10 also known as ADCY10 is an
enzyme that, in humans, is encoded by the ADCY10
gene .
[5]
Function
The protein encoded by this gene belongs to a distinct class of mammalian
adenylyl cyclase that is soluble and insensitive to
G protein or
forskolin regulation. It is localized in the
cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of
cAMP in
spermatozoa , implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the
acrosome reaction.
[6]
Clinical significance
Mutations in the ADCY10 gene are associated with an increased risk of adsorptive
hypercalciuria
[5] and
male infertility .
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000143199 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000026567 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Reed BY, Heller HJ, Gitomer WL, Pak CY (November 1999).
"Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24" . The Journal of Clinical Endocrinology and Metabolism . 84 (11): 3907–3913.
doi :
10.1210/jcem.84.11.6155 .
PMID
10566627 .
^
"Entrez Gene: ADCY10" .
^ Akbari A, Pipitone GB, Anvar Z, Jaafarinia M, Ferrari M, Carrera P, et al. (June 2019). "ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria". Human Reproduction . 34 (6): 1155–1164.
doi :
10.1093/humrep/dez048 .
PMID
31119281 .
External links
Further reading
Hukovic N, Panetta R, Kumar U, Rocheville M, Patel YC (August 1998).
"The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization" . The Journal of Biological Chemistry . 273 (33): 21416–21422.
doi :
10.1074/jbc.273.33.21416 .
PMID
9694905 .
Buck J, Sinclair ML, Schapal L, Cann MJ, Levin LR (January 1999).
"Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals" . Proceedings of the National Academy of Sciences of the United States of America . 96 (1): 79–84.
Bibcode :
1999PNAS...96...79B .
doi :
10.1073/pnas.96.1.79 .
PMC
15096 .
PMID
9874775 .
Hayes JS, Lawler OA, Walsh MT, Kinsella BT (August 1999).
"The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling" . The Journal of Biological Chemistry . 274 (34): 23707–23718.
doi :
10.1074/jbc.274.34.23707 .
PMID
10446129 .
Sinclair ML, Wang XY, Mattia M, Conti M, Buck J, Wolgemuth DJ, et al. (May 2000). "Specific expression of soluble adenylyl cyclase in male germ cells". Molecular Reproduction and Development . 56 (1): 6–11.
doi :
10.1002/(SICI)1098-2795(200005)56:1<6::AID-MRD2>3.0.CO;2-M .
PMID
10737962 .
S2CID
34539645 .
Chen Y, Cann MJ, Litvin TN, Iourgenko V, Sinclair ML, Levin LR, et al. (July 2000). "Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor". Science . 289 (5479): 625–628.
Bibcode :
2000Sci...289..625C .
doi :
10.1126/science.289.5479.625 .
PMID
10915626 .
Jaiswal BS, Conti M (August 2001).
"Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase" . The Journal of Biological Chemistry . 276 (34): 31698–31708.
doi :
10.1074/jbc.M011698200 .
PMID
11423534 .
Reed BY, Gitomer WL, Heller HJ, Hsu MC, Lemke M, Padalino P, et al. (April 2002).
"Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density" . The Journal of Clinical Endocrinology and Metabolism . 87 (4): 1476–1485.
doi :
10.1210/jc.87.4.1476 .
PMID
11932268 .
Zippin JH, Chen Y, Nahirney P, Kamenetsky M, Wuttke MS, Fischman DA, et al. (January 2003).
"Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains" . FASEB Journal . 17 (1): 82–84.
doi :
10.1096/fj.02-0598fje .
PMID
12475901 .
S2CID
22099561 .
Litvin TN, Kamenetsky M, Zarifyan A, Buck J, Levin LR (May 2003).
"Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate" . The Journal of Biological Chemistry . 278 (18): 15922–15926.
doi :
10.1074/jbc.M212475200 .
PMID
12609998 .
Jaiswal BS, Conti M (September 2003).
"Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa" . Proceedings of the National Academy of Sciences of the United States of America . 100 (19): 10676–10681.
Bibcode :
2003PNAS..10010676J .
doi :
10.1073/pnas.1831008100 .
PMC
196863 .
PMID
12958208 .
Marjanovic JA, Li Z, Stojanovic A, Du X (November 2005).
"Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation" . The Journal of Biological Chemistry . 280 (45): 37430–37438.
doi :
10.1074/jbc.M506518200 .
PMID
16144836 .
Schmid A, Sutto Z, Nlend MC, Horvath G, Schmid N, Buck J, et al. (July 2007).
"Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP" . The Journal of General Physiology . 130 (1): 99–109.
doi :
10.1085/jgp.200709784 .
PMC
2154360 .
PMID
17591988 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
Activity Regulation Classification Kinetics Types