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Other names | N-[3-[4-(2-Diethylaminoethoxy)phenyl]-1-(dipropylamino)-1-oxopropan-2-yl]benzamide |
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Chemical and physical data | |
Formula | C28H41N3O3 |
Molar mass | 467.654 g·mol−1 |
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Tiropramide ( INN) is an antispasmodic. [1]
The acylation of DL-Tyrosine [556-03-6] (1) with benzoyl chloride gives N,O-dibenzoyl-Tyrosine [14325-35-0] (2). Esterification with n-dipropylamine [142-84-7] (3) via the mixed anhydride method gave N,O-Dibenzoyl-DL-tyrosyl-N',N'-dipropylamide [57227-08-4] (4). Saponification of the ester in base gave N-Benzoyl-DL-tyrosyl-N',N'-dipropylamide [57227-09-5] (5). Ether formation with 2-Chlorotriethylamine [100-35-6] (6) completed the synthesis of Tiropramide (7).