This is the only protein family known, as of January 2021, to confer this activity.
Deoxyribodipyrimidine endonucleosidase (
EC3.2.2.17, pyrimidine dimer DNA-glycosylase, endonuclease V, deoxyribonucleate pyrimidine dimer glycosidase, pyrimidine dimer DNA glycosylase, T4-induced UV endonuclease, PD-DNA glycosylase) is an
enzyme with
systematic namedeoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase.[1] This enzyme
catalyses the following
chemical reaction
The only family of enzymes known to have this activity is represented by a
phage T4 protein. This family also has
AP lyase activity against the
AP site produced by this reaction.
References
^Haseltine WA, Gordon LK, Lindan CP, Grafstrom RH, Shaper NL, Grossman L (June 1980). "Cleavage of pyrimidine dimers in specific DNA sequences by a pyrimidine dimer DNA-glycosylase of M. luteus". Nature. 285 (5767): 634–41.
Bibcode:
1980Natur.285..634H.
doi:
10.1038/285634a0.
PMID6248789.
S2CID2811671.