| 4-oxoproline reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.104 | ||||||||
| CAS no. | 37250-37-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a 4-oxoproline reductase ( EC 1.1.1.104) is an enzyme that catalyzes the chemical reaction
- 4-oxo-L-proline + NADH + H+ cis-4-hydroxy-L-proline + NAD+
Thus, the three substrates of this enzyme are 4-oxo-L-proline, NADH, and H+, whereas its two products are cis- 4-hydroxy-L-proline and NAD+. [1]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxy-L-proline:NAD+ oxidoreductase. This enzyme is also called hydroxy-L-proline oxidase. This enzyme was originally thought to participate in the metabolism of arginine and proline. However, recent data show that it is unlikely since neither 4-oxo-L-proline nor cis-4-hydroxy-L-proline are metabolites of these metabolic pathways.
Gene
The gene encoding 4-oxo-L-proline reductase was identified as 3-hydroxybutyrate dehydrogenase 2 (BDH2) by Sebastian Kwiatkowski and co-workers in 2022. [1] The enzyme is a member of the Short-chain Dehydrogenases/Reductases (SDR) family of enzymes.
References
- ^ a b Kwiatkowski S, Bozko M, Zarod M, Witecka A, Kocdemir K, Jagielski AK, Drozak J (February 2022). "Recharacterization of the Mammalian Cytosolic Type 2 (R)-β-Hydroxybutyrate Dehydrogenase (BDH2) as 4-Oxo-L-Proline Reductase (EC 1.1.1.104)". The Journal of Biological Chemistry: 101708. doi: 10.1016/j.jbc.2022.101708. PMC 8914325. PMID 35150746.
Further reading
