From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Serine/threonine-protein kinase WNK3 , also known as protein kinase lysine-deficient 3 , is a
protein that in humans is encoded by the WNK3
gene .
[5]
Function
WNK3 is a protein belonging to the 'with no lysine' family of
serine-threonine protein kinases . These family members lack the catalytic
lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular
Ca2+ transport pathway, and it plays a role in the increase of cell survival in a
caspase 3 dependent pathway.
[5]
References
Further reading
Ross MT, Grafham DV, Coffey AJ, et al. (2005).
"The DNA sequence of the human X chromosome" . Nature . 434 (7031): 325–37.
Bibcode :
2005Natur.434..325R .
doi :
10.1038/nature03440 .
PMC
2665286 .
PMID
15772651 .
Nagase T, Kikuno R, Nakayama M, et al. (2000).
"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (4): 273–81.
doi :
10.1093/dnares/7.4.271 .
PMID
10997877 .
Yang CL, Zhu X, Ellison DH (2007).
"The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex" . J. Clin. Invest . 117 (11): 3403–11.
doi :
10.1172/JCI32033 .
PMC
2045602 .
PMID
17975670 .
Rinehart J, Kahle KT, de Los Heros P, et al. (2005).
"WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl− cotransporters required for normal blood pressure homeostasis" . Proc. Natl. Acad. Sci. U.S.A . 102 (46): 16777–82.
Bibcode :
2005PNAS..10216777R .
doi :
10.1073/pnas.0508303102 .
PMC
1283841 .
PMID
16275913 .
Ko B, Hoover RS (2009).
"Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter" . Curr. Opin. Nephrol. Hypertens . 18 (5): 421–7.
doi :
10.1097/MNH.0b013e32832f2fcb .
PMC
2947818 .
PMID
19636250 .
San-Cristobal P, Ponce-Coria J, Vázquez N, et al. (2008).
"WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+ -Cl− cotransporter" . Am. J. Physiol. Renal Physiol . 295 (4): F1199-206.
doi :
10.1152/ajprenal.90396.2008 .
PMC
2576145 .
PMID
18701621 .
Glover M, Zuber AM, O'Shaughnessy KM (2009).
"Renal and brain isoforms of WNK3 have opposite effects on NCCT expression" . J. Am. Soc. Nephrol . 20 (6): 1314–22.
doi :
10.1681/ASN.2008050542 .
PMC
2689907 .
PMID
19470686 .
Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III . 318 (2): 263–72.
PMID
7757816 .
Kahle KT, Ring AM, Lifton RP (2008). "Molecular physiology of the WNK kinases". Annu. Rev. Physiol . 70 : 329–55.
doi :
10.1146/annurev.physiol.70.113006.100651 .
PMID
17961084 .
Zhang W, Na T, Peng JB (2008).
"WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway" . Am. J. Physiol. Renal Physiol . 295 (5): F1472-84.
doi :
10.1152/ajprenal.90229.2008 .
PMC
2584897 .
PMID
18768590 .
Veríssimo F, Silva E, Morris JD, et al. (2006). "Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway". Oncogene . 25 (30): 4172–82.
doi :
10.1038/sj.onc.1209449 .
PMID
16501604 .
S2CID
20133914 .
Moniz S, Jordan P (2010).
"Emerging roles for WNK kinases in cancer" . Cell. Mol. Life Sci . 67 (8): 1265–76.
doi :
10.1007/s00018-010-0261-6 .
PMC
11115774 .
PMID
20094755 .
S2CID
32790065 .
Talmud PJ, Drenos F, Shah S, et al. (2009).
"Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip" . Am. J. Hum. Genet . 85 (5): 628–42.
doi :
10.1016/j.ajhg.2009.10.014 .
PMC
2775832 .
PMID
19913121 .
Qiao Y, Liu X, Harvard C, et al. (2008). "Autism-associated familial microdeletion of Xp11.22". Clin. Genet . 74 (2): 134–44.
doi :
10.1111/j.1399-0004.2008.01028.x .
PMID
18498374 .
S2CID
22008997 .
Wilson FH, Disse-Nicodème S, Choate KA, et al. (2001). "Human hypertension caused by mutations in WNK kinases". Science . 293 (5532): 1107–12.
doi :
10.1126/science.1062844 .
PMID
11498583 .
S2CID
22700809 .
Heise CJ, Xu BE, Deaton SL, et al. (2010).
"Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members" . J. Biol. Chem . 285 (33): 25161–7.
doi :
10.1074/jbc.M110.103432 .
PMC
2919078 .
PMID
20525693 .
Holden S, Cox J, Raymond FL (2004). "Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3)". Gene . 335 : 109–19.
doi :
10.1016/j.gene.2004.03.009 .
PMID
15194194 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Veríssimo F, Jordan P (2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms". Oncogene . 20 (39): 5562–9.
doi :
10.1038/sj.onc.1204726 .
PMID
11571656 .
S2CID
24494637 .
Bailey SD, Xie C, Do R, et al. (2010).
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study" . Diabetes Care . 33 (10): 2250–3.
doi :
10.2337/dc10-0452 .
PMC
2945168 .
PMID
20628086 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
Activity Regulation Classification Kinetics Types