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Class of enzymes
Very-long-chain enoyl-CoA reductase (
EC
1.3.1.93, TSC13 (gene name), CER10 (gene)) is an
enzyme with
systematic name very-long-chain acyl-CoA:NADP+ oxidoreductase.
[1]
[2]
[3]
[4] This enzyme
catalyses the following
chemical reaction
- a very-long-chain acyl-CoA + NADP+
a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH + H+
This is the fourth component of the
elongase, a microsomal protein complex responsible for extending
palmitoyl-CoA and
stearoyl-CoA.
References
-
^ Kohlwein SD, Eder S, Oh CS, Martin CE, Gable K, Bacikova D, Dunn T (January 2001).
"Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae". Molecular and Cellular Biology. 21 (1): 109–25.
doi:
10.1128/MCB.21.1.109-125.2001.
PMC
88785.
PMID
11113186.
-
^ Gable K, Garton S, Napier JA, Dunn TM (February 2004).
"Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system". Journal of Experimental Botany. 55 (396): 543–5.
doi:
10.1093/jxb/erh061.
PMID
14673020.
-
^ Kvam E, Gable K, Dunn TM, Goldfarb DS (September 2005).
"Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles". Molecular Biology of the Cell. 16 (9): 3987–98.
doi:
10.1091/mbc.E05-04-0290.
PMC
1196313.
PMID
15958487.
-
^ Zheng H, Rowland O, Kunst L (May 2005).
"Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis". The Plant Cell. 17 (5): 1467–81.
doi:
10.1105/tpc.104.030155.
PMC
1091768.
PMID
15829606.
External links
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