From Wikipedia, the free encyclopedia
UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase (
EC
2.6.1.98 , WbpE , WlbC ) is an
enzyme with
systematic name UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate:2-oxoglutarate aminotransferase .
[1]
[2]
[3] This enzyme
catalyses the following
chemical reaction
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate +
2-oxoglutarate
⇌
{\displaystyle \rightleftharpoons }
UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + L-
glutamate
This enzyme is a
pyridoxal 5'-phosphate protein.
References
^ Westman EL, McNally DJ, Charchoglyan A, Brewer D, Field RA, Lam JS (May 2009).
"Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa" . The Journal of Biological Chemistry . 284 (18): 11854–62.
doi :
10.1074/jbc.M808583200 .
PMC
2673254 .
PMID
19282284 .
^ Larkin A, Imperiali B (June 2009).
"Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1" . Biochemistry . 48 (23): 5446–55.
doi :
10.1021/bi900186u .
PMC
2694220 .
PMID
19348502 .
^ Larkin A, Olivier NB, Imperiali B (August 2010).
"Structural analysis of WbpE from Pseudomonas aeruginosa PAO1: a nucleotide sugar aminotransferase involved in O-antigen assembly" . Biochemistry . 49 (33): 7227–37.
doi :
10.1021/bi100805b .
PMC
2923267 .
PMID
20604544 .
External links
Activity Regulation Classification Kinetics Types