From Wikipedia, the free encyclopedia
Species of virus
Tylonycteris bat coronavirus HKU4 (Bat-CoV HKU4 ) is an enveloped,
positive-sense single-stranded RNA virus mammalian Group 2
Betacoronavirus that has been found to be genetically related to the
Middle East respiratory syndrome-related coronavirus (MERS-CoV ) that is responsible for the
2012 Middle East respiratory syndrome coronavirus outbreak in
Saudi Arabia ,
Jordan ,
United Arab Emirates , the
United Kingdom ,
France , and
Italy .
[1]
[2]
[3]
[4]
Transmission
The exact means of transmission to humans is not yet well known. However, it has been demonstrated that betaCoV's including HKU4 have the propensity to recombine and cause interspecies transmission. However, this is not seen in Group C betaCov's to which MERS-CoV is most closely related.
[5]
See also
References
^ Woo, Patrick CY; Lau, Susanna KP; Li, Kenneth SM; Tsang, Alan KL;
Yuen, Kwok-Yung (2012).
"Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5" . Emerging Microbes & Infections . 1 (11): e35–.
doi :
10.1038/emi.2012.45 .
PMC
3630921 .
PMID
26038405 .
^ Zaki, Ali M.; Van Boheemen, Sander; Bestebroer, Theo M.; Osterhaus, Albert D.M.E.; Fouchier, Ron A.M. (2012).
"Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia" . New England Journal of Medicine . 367 (19): 1814–20.
doi :
10.1056/NEJMoa1211721 .
PMID
23075143 .
^ Woo, Patrick C.Y.; Lau, Susanna K.P.; Li, Kenneth S.M.; Poon, Rosana W.S.; Wong, Beatrice H.L.; Tsoi, Hoi-wah; Yip, Bethanie C.K.; Huang, Yi; Chan, Kwok-Hung;
Yuen, Kwok-Yung (2006).
"Molecular diversity of coronaviruses in bats" . Virology . 351 (1): 180–7.
doi :
10.1016/j.virol.2006.02.041 .
PMC
7111821 .
PMID
16647731 .
^ Lau, S. K. P.; Li, K. S. M.; Tsang, A. K. L.; Lam, C. S. F.; Ahmed, S.; Chen, H.; Chan, K.-H.; Woo, P. C. Y.;
Yuen, K.-Y. (2013).
"Genetic characterization of betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of Pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: Implications for the origin of the novel Middle East respiratory syndrome coronavirus" . Journal of Virology . 87 (15): 8638–50.
doi :
10.1128/JVI.01055-13 .
PMC
3719811 .
PMID
23720729 .
^ Woo, Patrick C. Y.; Huang, Yi; Lau, Susanna K. P.;
Yuen, Kwok-Yung (2010).
"Coronavirus Genomics and Bioinformatics Analysis" . Viruses . 2 (8): 1804–20.
doi :
10.3390/v2081803 .
PMC
3185738 .
PMID
21994708 .
External links
Tylonycteris bat coronavirus HKU4