| tryptophan 2-C-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.106 | ||||||||
| CAS no. | 126626-83-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a tryptophan 2-C-methyltransferase ( EC 2.1.1.106) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + L-tryptophan S-adenosyl-L-homocysteine + L-2-methyltryptophan
Thus, the two substrates of this enzyme are S-adenosyl methionine and L- tryptophan, whereas its two products are S-adenosylhomocysteine and L-2-methyltryptophan.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase. Other names in common use include tryptophan 2-methyltransferase, and S-adenosylmethionine:tryptophan 2-methyltransferase.
References
- Frenzel T, Zhou P, Floss HG (1990). "Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosylmethionine:tryptophan 2-methyltransferase". Arch. Biochem. Biophys. 278 (1): 35–40. doi: 10.1016/0003-9861(90)90227-P. PMID 2321967.
