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Alternative splicing of the Drosophila Transformer gene product.
Transformer (tra) is a family of genes which regulate
sex determination in insects such as flies.
[1]
[2] Among its effects, it (
P11596 ) regulates differences between males and females in
Drosophila fruit flies.
[3]
The tra-2 gene (
P19018 ) is needed for
sexual differentiation in female fruit flies, and for
spermatogenesis in the males. It is not in the same
protein family as tra , but instead works together with it in the splicing enhancer complex.
[4]
[5]
References
^ Verhulst EC, van de Zande L, Beukeboom LW (August 2010).
"Insect sex determination: it all evolves around transformer" (PDF) . Current Opinion in Genetics & Development . 20 (4): 376–383.
doi :
10.1016/j.gde.2010.05.001 .
hdl :
11370/2174764d-bd1b-4e1f-b142-90aced0c3e55 .
PMID
20570131 .
S2CID
205003182 .
^ An X, Ota T, O'Neil MT, Steinmann-Zwicky M, Yamamoto D, et al.
"tra - transformer" . Gene Review . Nature Genetics. Archived from
the original on 5 August 2021. Retrieved 7 December 2017 .
^ Rideout EJ, Narsaiya MS, Grewal SS (December 2015).
"The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size" . PLOS Genetics . 11 (12): e1005683.
doi :
10.1371/journal.pgen.1005683 .
PMC
4692505 .
PMID
26710087 .
^ Amrein H, Gorman M, Nöthiger R (December 1988). "The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein". Cell . 55 (6): 1025–1035.
doi :
10.1016/0092-8674(88)90247-4 .
PMID
3144434 .
S2CID
21183373 .
^
"Transformer-2 sex-determining protein" . UniProt. Retrieved 7 December 2017 .