This article needs to be updated.(August 2016) |
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ECHA InfoCard | 100.233.047 |
Chemical and physical data | |
Formula | C26H22ClF3N2O3 |
Molar mass | 502.92 g·mol−1 |
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(what is this?) (verify) |
Fluvalinate [1] is a synthetic pyrethroid chemical compound contained as an active agent in the products Apistan, [2] Klartan, and Minadox, that is an acaricide (specifically, a miticide), commonly used to control Varroa mites in honey bee colonies,[ citation needed] infestations that constitute a significant disease of such insects.
Fluvalinate is a stable, nonvolatile, [3] viscous, heavy oil (technical) soluble in organic solvents. [4] Although the compound may be found in drones, a study has found honey samples virtually absent of fluvalinate, on account of its affinity to beeswax. [5][ better source needed]
Fluvalinate is synthesized from racemic valine [(RS)-valine], the synthesis is not diastereoselective. Thus, fluvalinate is a mixture of four stereoisomers, each about 25%. [6]
(R,R)-configuration |
(S,S)-configuration |
(S,R)-configuration |
(R,S)-configuration |
Tau-fluvalinate (τ-fluvalinate) is the trivial name for (2R)-fluvalinate. The C atom in the valinate structure is in (R)- absolute configuration, while the second chiral atom is a mixture of (R)- and (S)-configurations: [4]
(R,R)-configuration |
(R,S)-configuration |
This report was commissioned by MAF to aid in internal decision making only. This report in no way constitutes MAF's advice to beekeepers and is useful only as background information.
Apistan is a product available that will kill the mites and cause the mites to drop from the bees. … Apistan strips, which contain the miticide fluvalinate, are available from most large beekeeping suppliers and can be used both for detection and treatment of varroa infestations.