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This is a table of drugs that are secreted in the kidney.

Acid medication are, because of pH partition, secreted to a higher extent when urine is basic. In the same way, basic medications are secreted to a higher extent when urine is acidic.

Medication Location Acid or base [1] anion or cation [2] Percentage excreted [3]
para-aminohippurate proximal tubule [4] Acid anion
furosemide proximal tubule [4] Acid anion 100-75
glucuronic acid-conjugates proximal tubule [4] Acid
glycine conjugates proximal tubule [4] Acid
indometacin proximal tubule [4] Acid anion
methotrexate proximal tubule [4] Acid 100-75
penicillin proximal tubule [4] Acid anion 75-50
( benzylpenicillin)
probenecid proximal tubule [4] Acid anion
sulphate conjugates proximal tubule [4] Acid
thiazide diuretics proximal tubule [4] Acid
uric acid proximal tubule [4] Acid
amiloride proximal tubule [4] Base cation
dopamine proximal tubule [4] Base
histamine proximal tubule [4] Base
mepacrine proximal tubule [4] Base
morphine proximal tubule [4] Base cation
pethidine proximal tubule [4] Base
quaternary ammonium compounds proximal tubule [4] Base
quinine proximal tubule [4] Base cation
5-hydroxytryptamine (serotonin) proximal tubule [4] Base
triamterene proximal tubule [4] Base
gentamicin 100-75
atenolol 100-75
digoxin 100-75
cimetidine cation 75-50
tetracycline 75-50
( oxytetracycline)
neostigmine 75-50
propantheline ~50
tubocurarine ~50
acetazolamide proximal tubule [5] anion
chlorothiazide proximal tubule [5] anion
saccharin proximal tubule [5] anion
salicylate proximal tubule [5] anion
atropine proximal tubule [5] cation
NMN proximal tubule [5] cation
paraquat proximal tubule [5] cation
procainamide proximal tubule [5] cation
tetraethylammonium proximal tubule [5] cation
chlorpromazine proximal tubule [5] cation

References

  1. ^ Unless else specified in table boxes, then ref is Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN  0-443-07145-4. Page 112
  2. ^ Unless else specified in table boxes, then ref is Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN  1-4160-2328-3. Page 802
  3. ^ Unless else specified in table boxes, then ref is Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN  0-443-07145-4. Page 113
  4. ^ a b c d e f g h i j k l m n o p q r s t u Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN  0-443-07145-4. Page 112
  5. ^ a b c d e f g h i j Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN  1-4160-2328-3. Page 802