From Wikipedia, the free encyclopedia
Class of enzymes
TRNA-dihydrouridine20 synthase (NAD(P)+) (
EC
1.3.1.91, Dus2p, tRNA-dihydrouridine synthase 2) is an
enzyme with
systematic name tRNA-5,6-dihydrouracil20:NAD(P)+ oxidoreductase.
[1]
[2]
[3]
[4] This enzyme
catalyses the following
chemical reaction
- 5,6-dihydrouracil20 in tRNA + NAD(P)+
uracil20 in tRNA + NAD(P)H + H+
This enzyme specifically modifies
uracil20 in
tRNA.
References
-
^ Xing F, Hiley SL, Hughes TR, Phizicky EM (April 2004).
"The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". The Journal of Biological Chemistry. 279 (17): 17850–60.
doi:
10.1074/jbc.M401221200.
PMID
14970222.
-
^ Xing F, Martzen MR, Phizicky EM (March 2002).
"A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA". RNA. 8 (3): 370–81.
doi:
10.1017/S1355838202029825.
PMC
1370258.
PMID
12003496.
-
^ Rider LW, Ottosen MB, Gattis SG, Palfey BA (April 2009).
"Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction". The Journal of Biological Chemistry. 284 (16): 10324–33.
doi:
10.1074/jbc.M806137200.
PMC
2667719.
PMID
19139092.
-
^ Kato T, Daigo Y, Hayama S, Ishikawa N, Yamabuki T, Ito T, Miyamoto M, Kondo S, Nakamura Y (July 2005).
"A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis". Cancer Research. 65 (13): 5638–46.
doi:
10.1158/0008-5472.CAN-05-0600.
PMID
15994936.
External links
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